- Factors associated with cannabis use among infertile patients and their partner. [Journal Article]J Assist Reprod Genet. 2026 Oct 31. [Online ahead of print]JA
- CONCLUSIONS: Cannabis use increased over the study period and clustered with other behavioral and psychosocial factors. Younger, non-married individuals and those reporting tobacco use or anxiety/depression may benefit from targeted cannabis screening and preconception counseling.
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- Expanded Carrier Screening in gamete donation identifies clinically relevant donor-recipient genetic incompatibilities. [Journal Article]
- CONCLUSIONS: ECS identified a substantial proportion of donor-recipient shared carrier findings. However, the clinical relevance and incremental contribution of ECS beyond standard donor screening depend on the specific condition and the genes and variants already assessed in the donor. These findings support the use of ECS as a broader approach to reproductive risk assessment, while highlighting the need for gene-level matching data to quantify its incremental clinical utility.
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- Artificial oocyte activation in patients with fertilization failure using calcium ionophores: a meta-analysis on reproductive outcomes. [Journal Article]
- CONCLUSIONS: Calcium ionophore-mediated activation may enhance reproductive outcomes in ICSI cycles in patients with fertilization failure, without increasing miscarriage or adverse neonatal outcomes. Their selective use could prevent cycle cancellation and reduce the emotional and financial burden associated with repeated ICSI failures. However, given the variability in ionophore protocols and experimental design, further randomized studies are warranted to standardize dosing, timing, and indications before universal clinical adoption.
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- Does blastocyst transfer have a higher live birth rate than cleavage-stage embryo transfer in patients with delayed in vitro blastocyst development? [Journal Article]
- CONCLUSIONS: When embryo cohorts exhibit delayed development at the blastocyst stage, blastocyst transfer does not result in a higher LBR and therefore may not confer an advantage in achieving live birth sooner compared with the transfer of good-quality cleavage-stage embryos.
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- Waived semen analyzers in clinical practice: analytical standards, regulatory categorization, and the limits of automated assessment. [Letter]
- CONCLUSIONS: Waived semen analyzers offer genuine advantages in workflow efficiency and intra-instrument reproducibility and are appropriate for preliminary assessment of major male factor causes of infertility. Documented limitations in morphology accuracy near the 4% Tygerberg threshold, motility detection at low values, and handling of complex samples make them insufficient as stand-alone replacements for qualified manual analysis in high-stakes contexts including azoospermia determination and pharmacologic research as well as studies on infertility pathophysiology and diagnosis, and fertility prognosis. The scope of the CLIA waivers is settled; the applicable CPT billing codes remain unresolved and require professional society engagement with the American Medical Association's (AMA's) CPT Editorial Panel. Laboratory validation is a professional obligation regardless of CLIA complexity level and is also required internationally by ISO 15189.
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- Selected abstracts from the 30[th] annual meeting of the AAB College of Reproductive Biology. [Journal Article]J Assist Reprod Genet. 2026 Oct 26. [Online ahead of print]JA
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- 150 years after Hertwig: how the discovery of fertilisation transformed reproductive medicine. [Review]
- The year 2026 marks the 150th anniversary of Oscar Hertwig's demonstration that fertilisation results from the fusion of sperm and oocyte, a discovery that fundamentally transformed biology and medicine. This historical review retraces the intellectual journey from ancient philosophical and theological interpretations of conception through the theories of spontaneous generation, preformationism, …
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- Access to pediatric ovarian and testicular tissue cryopreservation in the USA: a national survey of clinical delivery models and research practices. [Journal Article]
- CONCLUSIONS: Pediatric ovarian and testicular tissue cryopreservation in the USA functions through an informal, institutionally coordinated hub-and-spoke model of distributed surgical procurement and centralized cryopreservation. Variability in service roles, research oversight, and specimen utilization highlights opportunities to improve transparency, coordination, and access.
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- Sharing new genetic risk information with recipients of donor gametes. [Editorial]
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- Selected abstracts from the 14th Congress of Turkish Foundation of Reproductive Medicine: Oral presentations [OP-01-OP-81]. [Journal Article]J Assist Reprod Genet. 2026 Oct 19. [Online ahead of print]JA
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- X-linked novel hemizygous ADGRG2 variants associated with male factor infertility. [Journal Article]
- CONCLUSIONS: Our findings established ADGRG2 variants cause male infertility and may be the etiology of CBAVD, expanding the associated mutational spectrum and reinforcing the gene's critical role in male fertility, thereby supporting the integration of comprehensive ADGRG2 screening into clinical practice to enhance genetic and reproductive counseling for affected patients.
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- Not all Day-4 embryos are equal: developmental stage predicts outcomes after single embryo transfer. [Journal Article]
- CONCLUSIONS: Fresh day 4 embryo transfer outcomes are strongly influenced by embryonic developmental stage. Cleavage-stage embryos on day 4 are associated with poor pregnancy rates and may benefit from extended culture. In contrast, day 4 morula or blastocyst transfer represents a viable clinical option, particularly when logistical constraints preclude day 5 transfer.
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- Novel heterozygous GMNN variants in human early embryonic arrest involving CHK1‑mediated cell cycle dysregulation. [Journal Article]
- CONCLUSIONS: Our findings expand the mutational and phenotypic spectrum of GMNN‑associated infertility and reinforce its critical role in cell cycle control during preimplantation development. The distinct transcriptomic signatures arising from different GMNN variants provide mechanistic insights into embryo arrest and offer potential molecular diagnostic markers as well as avenues for individualized therapeutic strategies.
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- Obesity and morbid obesity are associated with reductions in live birth rate and increased miscarriage rate after frozen embryo transfer. [Journal Article]
- CONCLUSIONS: Increasing BMI is associated with lower LBR and CIUPR, following FET, including SEETs. MR increased with BMI for all FETs, with a similar but non-significant gradient among SEETs. This highlights the importance of considering BMI when counseling patients, particularly those with morbid obesity.
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