- Neuroendocrine regulation of adipose partitioning in polyendocrine metabolic ovarian syndrome: the gut-brain-adipose axis. [Review]
- CONCLUSIONS: This review discusses the gut-brain-adipose axis as a conceptual framework for understanding how neuroendocrine signaling influences adipose tissue distribution and insulin resistance in PMOS. Further understanding of the gut-brain-adipose axis may help identify potential therapeutic targets for improving metabolic health in women with PMOS.
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- Worse muscle mass loss in adrenal Cushing syndrome vs. Cushing's disease: a comparative evaluation of chemiluminescence and LC-MS/MS cortisol assessment. [Journal Article]
- CONCLUSIONS: In premenopausal women, the muscle mass with CD is significantly higher than that with ACS. This may indicate a higher severity of myopathy in ACS patients. Muscle wasting in Cushing's syndrome represents a multifactorial process driven by mechanical load, subtype-specific androgen status, and cortisol exposure. Furthermore, CL cortisol offers a reliable, accessible first-line assessment tool, while LC-MS/MS provides added value through multi-steroid profiling.
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- The association between androgenic profile and cardiometabolic risk factors in young men: insights from a large observational cohort study. [Journal Article]
- CONCLUSIONS: In young adult men, androgenic profile was found to be robustly associated with mCVR factors; however, causality and temporal directionality cannot be inferred because of the cross-sectional design of the study.
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- Predictors of prolonged hypogonadism in men with prolactinomas despite biochemical remission: the role of baseline luteinizing hormone. [Journal Article]J Endocrinol Invest. 2026 Sep 30. [Online ahead of print]JE
- CONCLUSIONS: Baseline LH was strongly associated with prolonged hypogonadism in prolactinomas and may serve as a marker for early risk stratification. Most hormonal recovery occurred within the first 12 months after prolactin normalization, supporting the clinical relevance of this time point. Baseline hormonal and structural parameters may help guide follow-up and testosterone replacement decisions.
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- C-reactive protein-triglyceride-glucose index and incident mild cognitive impairment among patients with cardiovascular-kidney-metabolic syndrome: a dual-cohort prediction and double machine learning analysis. [Journal Article]
- CONCLUSIONS: CTI reliably predicts incident MCI in patients with CKM syndrome. The gradient boosting framework provides a robust risk stratification, and higher cognitive reserve may attenuate CTI-associated cognitive risk.
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- Body roundness index shows a short-term, sex-specific advantage over body mass index in predicting incident diabetes: a longitudinal prospective cohort study. [Journal Article]
- CONCLUSIONS: In this cohort study, baseline BRI was associated with an increased risk of DM incidence, and BRI showed superior discriminatory performance relative to BMI specifically for short-term (4-5 year) prediction, particularly among women.
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- Cumulative metabolic burden and urinary albumin-to-creatinine ratio in non-diabetic adults: a nationwide population-based study. [Journal Article]
- CONCLUSIONS: Cumulative metabolic abnormality burden was independently associated with higher urinary ACR in adults without diabetes. These findings should be interpreted as hypothesis-generating and suggest that adults without diabetes but with clustered metabolic abnormalities may warrant further longitudinal evaluation for kidney risk stratification.
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- Leg fat-to-total fat ratio improves waist-to-height ratio for discriminating metabolic syndrome: a nationwide cross-sectional study. [Journal Article]
- CONCLUSIONS: WHtR was the strongest individual anthropometric discriminator of MetS, but incorporating the LF/TF ratio further improved discrimination, particularly among younger adults. These findings suggest the clinical relevance of DXA-derived lower-extremity fat distribution as a complement to central adiposity for MetS discrimination. Prospective studies in diverse populations are warranted to validate this approach.
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- Adrenal incidentalomas: 1 mg dexamethasone test result in the context of cardiometabolic risk. [Journal Article]
- CONCLUSIONS: Post-DST cortisol concentrations below the standard cutoff may be associated with cardiometabolic comorbidities in patients with adrenal incidentalomas. These findings should be interpreted with caution and require confirmation in prospective studies.
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- Association between annual air pollutant exposure and thyroid function: a retrospective cross-sectional study. [Journal Article]
- CONCLUSIONS: Yearly exposure levels of air pollutants were positively associated with TSH, negatively associated with FT4 levels, and significantly associated with high TSH-low FT4. These findings suggest that exposure to ambient air pollution may contribute to thyroid function alterations at the population level, highlighting the importance of air quality improvement. Further longitudinal studies were warranted to consolidate these findings.
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- Spatial correspondence between altered brain function and normative neurotransmitter density maps in Type 1 diabetes mellitus. [Journal Article]
- CONCLUSIONS: This study demonstrates spatial correspondences between T1DM-related brain functional alterations and normative distributions of multiple neurotransmitter receptors/transporters. The negative correlation between thalamic ALFF and HbA1c suggests an association between chronic hyperglycemia and local brain activity. These findings offer a novel perspective on the pathophysiology of cognitive impairment in T1DM.
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- Salivary hormones and adipokines are associated with glycemic control and early renal and cardiometabolic markers in children and young adults with type 1 diabetes. [Journal Article]
- CONCLUSIONS: Salivary metabolic hormones and adipokines are associated with early markers of metabolic and vascular dysfunction in young individuals with T1D, independently of weight status. These findings suggest a potential role for these biomarkers in early diabetes-related complications.
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- Body mass index outperforms the Rotterdam criteria in defining phenotypic heterogeneity in polycystic ovary syndrome: a multicenter study from the Italian PCOS registry (PCOSOUTCOME.net). [Multicenter Study]
- CONCLUSIONS: In this multicenter cohort, Rotterdam phenotypes failed to discriminate metabolic risk, whereas BMI-based stratification proved more informative in identifying cardiometabolic complications. Moreover, obesity in PCOS identifies a distinct hyperandrogenic phenotype. These findings underscore the need to integrate BMI into the classification of PCOS to better capture patient heterogeneity, with potential implications for metabolic assessment and risk stratification.
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- Prediabetes: diagnostic aspects, clinical features, and emerging therapeutic opportunities, with a focus on Vitamin D. [Journal Article]
- CONCLUSIONS: Given the growing clinical and public health burden of prediabetes, early identification and personalized preventive strategies are needed. Current evidence supports consideration of vitamin D supplementation as a complementary intervention in selected high-risk individuals with documented deficiency, while further studies are required to better define optimal treatment targets and patient selection criteria.
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