- Interlocking pentagons task and visuospatial deficit in parkinsonian syndrome: a quantitative approach. [Journal Article]
- CONCLUSIONS: This study demonstrates that quantitative scoring of the MMSE pentagon-copying item could differentiate PD from APS. The presence of association between QSPT and MRI brainstem morphometry could also reflect a structural association, specifically identifying tauopathies. QSPT could be a simple and supportive clinical tool, embedded within the MMSE that could differentiates patients from HC and PD from APS.
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- Intravenous thrombolysis use before interhospital transfer for thrombectomy: a systematic review and meta-analysis. [Systematic Review]J Neurol. 2026 Sep 28; 273(10).JN
- CONCLUSIONS: Among LVO-AIS patients requiring interhospital transfer from PSCs to CSCs for EVT, pre-transfer IVT was associated with improved functional outcomes and interhospital recanalization, without increasing hemorrhagic risk. These findings support pre-transfer IVT as an effective reperfusion strategy in resource‑limited settings where timely EVT is not immediately accessible.
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- Progressive motor impairment from intracerebral critical demyelinating lesions. [Journal Article]
- CONCLUSIONS: Intracerebral critical demyelinating lesions associated with progressive motor impairment can rarely occur along the corticospinal tracts of the brain.
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- Evaluating the neurofilament light chain-derived gap between biological and chronological age in multiple sclerosis and controls. [Journal Article]
- CONCLUSIONS: MS is associated with a shift in age-associated NfL trajectory, with an older biological profile especially in pwMS with greater disability and progressive course.
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- The role of leukocyte p38 MAP kinase in immune-mediated peripheral polyneuropathies: distinct modulation by intravenous immunoglobulins. [Journal Article]
- CONCLUSIONS: Together, this exploratory study indicates that leukocyte p38 MAPK modulation might be involved in disease activity and therapeutic effect of IVIg in MMN, but not CIDP.
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- Real-space navigation in patients with focal epilepsy underpins the prominent role of the hippocampus for allocentric navigation in humans. [Journal Article]
- CONCLUSIONS: This study supports the hippocampus as a major hub for human goal-oriented navigation in real environments, with right hippocampal dysfunction particularly impairing allocentric navigation and creation of novel routes.
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- Family history of multiple sclerosis and long-term outcomes. [Journal Article]
- CONCLUSIONS: Family history of MS did not appear to have a substantial prognostic impact on long-term disease outcomes after MS onset.
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- Leisure-time physical activity, sun exposure, and multiple sclerosis risk: a population-based case-control study. [Journal Article]
- CONCLUSIONS: The overall association between leisure-time physical activity and MS risk was attenuated after adjustment for lifestyle and environmental factors. Inverse associations among individuals with low sun exposure and in analyses accounting for outdoor activity suggest a possible context-dependent association.
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- Late-onset CMT neuropathy in the NGS era: a 10-year retrospective study. [Journal Article]
- CONCLUSIONS: Late-onset CMT accounts for a substantial proportion of neuropathies after age 50. Family history, pes cavus, and slowed median nerve conduction should prompt comprehensive genetic testing, particularly including genes associated with late-onset phenotypes.
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- Dorsal and ventral stream visuoperceptual processing deficits in Lewy body disease. [Journal Article]
- CONCLUSIONS: Early dorsal and ventral stream impairments are a hallmark of dementia in LBD, differing quantitatively and qualitatively from AD. These deficits in LBD were more pronounced than those of attention and executive function.
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- VEP latency delays predicts MRI neurodegenerative outcomes in multiple sclerosis. [Journal Article]J Neurol. 2026 Sep 25; 273(10).JN
- CONCLUSIONS: VEP-based P100 latency shows both age- and RNFL-independent associations with MRI-based MS outcomes. In addition to their established diagnostic utility, VEP measures may provide a neurophysiological, objective metric to assess neurodegeneration.
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- The link between plasma and cognitive markers for Alzheimer's disease in Down syndrome: a longitudinal study. [Journal Article]
- CONCLUSIONS: These findings highlight the relevance of episodic memory performance as a predictor of biomarker progression, particularly p-tau217, and support its close association with clinical status and disease progression. The results support the development of screening strategies to identify DS individuals at high risk of rapid cognitive decline and to inform future therapeutic trials.
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- Pharmacological treatment of sleep disorder phenotypes in Parkinson's disease: a systematic review and meta-analysis of randomised controlled trials. [Systematic Review]
- CONCLUSIONS: Pharmacological treatment, particularly with chronobiotic agents and dopaminergic receptor agonists, may produce improvement in overall sleep quality (low-certainty evidence). Evidence for EDS, insomnia symptoms, and RBD remains insufficient for definitive recommendations, and pooled estimates in these domains should not be over-interpreted given their very high statistical heterogeneity. Phenotype-specific RCTs with harmonised outcome measures are needed.
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- What have trials targeting amyloid in Alzheimer's told us to date? The conversation the Alzheimer's field isn't having. [Journal Article]
- A recent systematic review concluded that anti-amyloid therapies for Alzheimer's disease offer no clinically meaningful benefit, drawing sharp criticism that focused largely on the review's methodology rather than on the clinical case for the drugs themselves. This Comment examines what the currently licensed treatments deliver for patients and what terms, such as 'modest' and 'moderate', benefit…
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- Frequency-Specific EEG burst dynamics in Parkinson's Disease and freezing of gait. [Journal Article]
- CONCLUSIONS: Resting-state EEG burst dynamics reveal dissociable oscillatory signatures in PD. Low-beta burst timing abnormalities reflect general PD-related motor network dysfunction, whereas theta burst amplitude may relate to FOG severity and cognitive-motor network burden.
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