- Intracranial Metastasis From Medullary Thyroid Carcinoma Mimicking As Invasive Meningioma: A Case Series. [Case Reports]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S39.JP
- CONCLUSIONS: Medullary thyroid carcinoma can metastasize to the brain and mimic primary CNS tumours such as meningioma on imaging, despite this being rare. A high index of suspicion and thorough metastatic workup are warranted whenever an intracranial lesion is encountered, and whole-body screening should be considered whenever a primary malignancy is identified, regardless of how uncommon its metastatic spread may be.
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- Carboplatin and Etoposide as Effective Fourth-Line Treatment in a patient with Recurrent Oligodendroglioma Complicated by Therapy-Related Acute Myeloid Leukaemia. [Case Reports]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S38.JP
- CONCLUSIONS: Carboplatin and etoposide may be considered a viable salvage treatment option for heavily pretreated patients with recurrent oligodendroglioma who have progressed through multiple prior lines of therapy, offering meaningful survival benefit even in the fourth-line setting. However, this case underscores the importance of vigilant long-term monitoring for serious late toxicities, particularly Acute Myeloid Leukaemia.
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- Beyond the brain and barrier: high-grade astrocytoma with distant metastases in a young patient - a rare presentation. [Case Reports]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S37.JP
- CONCLUSIONS: Immunophenotyping separates true metastasis from a second cancer.
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- En Bloc Resection of a Giant Sacrococcygeal Chordoma Presenting with Urinary Bladder Distension to the L4 Level: A Case Report. [Case Reports]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S36.JP
- CONCLUSIONS: This is the first reported sacrococcygeal chordoma with L4-level bladder distension from mechanical obstruction. Nerve-sparing en bloc R0 resection achieved full functional recovery, highlighting multidisciplinary planning and intraoperative neuromonitoring.
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- Paediatric Scalp Squamous Cell Carcinoma With Suspected Intracranial Extension Mimicking Cerebral Abscesses in a Patient With Xeroderma Pigmentosum: A Case Report and Literature Review Abstract. [Case Reports]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S35.JP
- CONCLUSIONS: XP-associated scalp SCC may behave aggressively and extend intracranially, even in children. In patients with a history of malignancy, intracranial lesions with an apparent infectious appearance should prompt careful consideration of tumour extension in the differential diagnosis. Recognition of suspicious neuroimaging features, careful radiologic-pathologic correlation, early multidisciplinary evaluation, and timely management are essential to optimize outcomes.The parents consented to publish the child's report in detail.
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- Glymphatic dysfunction following traumatic brain injury: Mechanism of waste clearance and Emerging therapeutic targets. [Review]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S34.JP
- CONCLUSIONS: Our review highlights the disruption of glymphatic function as part of TBI pathophysiology and focusses on diagnostic tools and emerging treatment modalities. Further human studies are required, as most evidence comes from murine models. Moreover, studies are needed to assess therapeutic interventions involving hypothermia and aquaporin-4 on TBI-induced glymphatic dysfunction.
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- Real-World Barriers to Molecular Biomarker Testing in Neuro-Oncology Clinical Trials in Resource-Limited Settings: A Scoping Review. [Journal Article]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S33.JP
- CONCLUSIONS: Biomarker testing facility gaps constitute a major, modifiable obstacle to LMIC participation in neurooncology trials. Implementing a collaborative and structured approach to investment in diagnostics, standardized reporting, and international collaboration is essential for LMIC engagement with trials. Future trial designs should incorporate multi-tiered approaches to biomarkers reflecting available laboratory capacity in different locations.
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- Childhood and Adolescent Central Nervous System Tumour Mortality in the United States, 1999- 2024: A CDC WONDER Joinpoint Analysis and Surveillance Model for Pakistan. [Journal Article]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S32.JP
- CONCLUSIONS: Childhood and adolescent CNS tumour mortality in the United States demonstrated a modest but significant decline between 1999 and 2024, while maintaining a persistent male predominance. This populationbased analysis provides an evidence-based framework for monitoring paediatric neuro-oncology outcomes and offers a scalable surveillance model for countries without national cancer mortality registries, including Pakistan.
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- Comparative Analysis of Prognostic Scoring Systems for Survival Prediction in Patients Undergoing Surgery for Spinal Metastases: A GRADE-approached Systematic Review and Meta-Analysis. [Systematic Review]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S31.JP
- CONCLUSIONS: As prognostic models exhibit only moderate accuracy in survival prediction, with the SORG Nomogram performing best. Integration of such models within multidisciplinary frameworks like LMNOP may improve individualized surgical planning and optimize patient outcomes with metastatic spine disease.
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- Survival Impact of Supramarginal Resection According to MGMT Promoter Methylation Status in Glioblastoma: A Systematic Review and Meta-analysis. [Systematic Review]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S30.JP
- CONCLUSIONS: SMR was associated with improved survival irrespective of MGMT promoter methylation status. However, the evidence is predominantly observational and susceptible to confounding. Randomized controlled trials are required before SMR can be recommended as routine surgical practice.
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- Clinical Pattern And Surgical Outcomes Of Meningioma. [Journal Article]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S29.JP
- CONCLUSIONS: Most patients with meningioma had favourable surgical outcomes following resection. Postoperative wound infection and new neurological deficits occurred in a minority of patients. Careful surgical planning and appropriate postoperative management remain important for optimizing outcomes.
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- Preoperative identity Threat and Illness Perception in Patients Undergoing Resection of Intracranial Tumours: A Multidimensional Cross-sectional Study Using Validated Psychometric Instruments. [Journal Article]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S28.JP
- CONCLUSIONS: Among patients undergoing intracranial tumour resection, stronger illness perception was associated with lower preoperative decisional conflict. However, anxiety, depression, perceived social support were not significantly related to decisional conflict.
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- Urban-Rural Disparities in Malignant Brain Tumour Mortality in the United States, 1999-2020: A CDC WONDER Join point Analysis with Relevance to Neurosurgical Access in Pakistan. [Journal Article]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S27.JP
- CONCLUSIONS: US malignant brain tumour mortality followed a persistent urban-to-rural gradient from 1999 to 2020, where it was lowest in large metropolitan cores and highest in nonmetropolitan areas, with parallel trends that left the gap intact. As an ecological analysis, it cannot establish causation. This reproducible CDC WONDER Join point method offers a template for mapping neurosurgical-access disparities in settings such as Pakistan.
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- Hybrid Quantum-Classical Predictive Modelling for Glioblastoma Survival: Addressing Data Scarcity in Resource-Constrained Neuro-Oncology. [Journal Article]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S26.JP
- CONCLUSIONS: This framework demonstrates that shifting the clinical focus from massive data accumulation to quantum-inspired algorithmic efficiency offers a scalable, low-cost path to personalized neuro-oncological care. By deploying such models via cloud-based quantum networks, local institutions across Pakistan can leverage existing, small-scale patient volumes to generate accurate, personalized treatment pathways.
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- Contribution of Unspecified Brain Malignancies to Overall Brain Cancer Mortality Trends in the United States: A 26 years CDC WONDER Analysis. [Journal Article]J Pak Med Assoc. 2026 Sep; 76(Suppl 1)(9):S25.JP
- CONCLUSIONS: Analysis reported higher burden of brain malignancy among the males, older ages, and Non-Hispanic white populations, Midwest, Non metropolitan areas highlighting diagnostic precision and targetted intervention.
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