- BRAP maintains SEC24D stability to regulate ER stress and promote cervical adenocarcinoma progression. [Journal Article]J Transl Med. 2026 Aug 13; 24(1).JT
- CONCLUSIONS: BRAP promotes cervical adenocarcinoma progression by maintaining SEC24D stability and preserving ERES organization and function, thereby sustaining COPII-dependent ER export and ER homeostasis. Disruption of the BRAP-SEC24D axis impairs ERES integrity, activates PERK-dependent ER stress, and suppresses malignant phenotypes. These findings identify BRAP as a previously unrecognized regulator of ER homeostasis and establish the BRAP-SEC24D signaling axis as a potential therapeutic target for cervical adenocarcinoma.
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- Macrophage-derived exosomes in bone tissue regeneration: spatiotemporal immunomodulation, engineering advances, and translational frontiers. [Review]J Transl Med. 2026 Jul 25; 24(1).JT
- CONCLUSIONS: By integrating the spatiotemporal functions of macrophage-derived exosomes (M-Exos) and single-cell-resolved landscapes of macrophage functional states, this review delineates the mechanistic links among macrophage state transitions, M-Exo cargo profiles, and regenerative outcomes across distinct phases of bone healing. It further provides a theoretical basis for developing stage-adaptive and functionally tunable M-Exo-based strategies for bone regeneration.
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- Single-cell transcriptomics reveals macrophage-neutrophil crosstalk in Haematitum-induced lung injury associated with gut dysbiosis. [Journal Article]J Transl Med. 2026 Sep 12; 24(1).JT
- CONCLUSIONS: This study has revealed a potential toxic mechanism. The intestinal barrier in mice was compromised, with an increase in the relative abundance of Klebsiella, entry of microbial metabolites into the bloodstream, and disruption of glycerophospholipid metabolism in the lungs, which in turn resulted in dysfunction of pulmonary immune cells. It clarifies that the core mechanism of Haematitum-induced lung injury lies in inhibiting the PPAR signaling pathway in macrophages and activating the TNF signaling pathway in neutrophils. Administering Haematitum at a common dose or in combination with Inula japonica Thunb. mitigates these safety risks. These findings advance understanding of the toxicology of mineral-based medicines and provide a reference for the safe clinical application of these traditional Chinese medicines.
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- Mechanisms and functions of the TRIM protein family in digestive system cancers. [Review]J Transl Med. 2026 Jul 27; 24(1).JT
- CONCLUSIONS: The modular architecture of TRIM proteins enables diverse substrate recognition and regulatory outputs. Cross-cancer analysis identifies pathway-convergent, phenotype-convergent, and pathway-phenotype bridging TRIM members that translate dysregulation of core pathways, including Wnt/β-catenin, PI3K/AKT, and p53, into proliferative, cell death-related, metastatic, metabolic, and immune phenotypes. Their functional direction is jointly shaped by tumor type, molecular subtype, substrate status, microenvironmental cues, and treatment context. Selected TRIM members show potential as prognostic biomarkers, risk-stratification indicators, and predictors of therapeutic response, whereas most TRIM-targeted strategies remain preclinical. Future studies should clarify ubiquitin-chain-specific regulatory logic, subtype-specific functions, and multilayered networks, while rigorously evaluating the specificity, safety, and clinical applicability of TRIM-directed combination therapies.
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- Shikonin triggers apoptosis in lung adenocarcinoma through the FHL2-FOXO1 signaling axis. [Journal Article]J Transl Med. 2026 Aug 25; 24(1).JT
- CONCLUSIONS: Our findings indicate a novel signaling pathway through which SHK inhibits LUAD: by directly targeting FHL2 for degradation, SHK disrupts the FHL2-FOXO1 complex, which activates FOXO1-mediated transcription and triggers apoptosis. This study not only provides mechanistic insight into the antitumor function of SHK but also identifies the FHL2-FOXO1 axis as a potential therapeutic target for LUAD.
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- Three-dimensional multimodal fractal dynamics integrating spatial metabolism, cytoarchitecture, and perfusion for preoperative prediction of microvascular invasion in colorectal liver metastases. [Journal Article]J Transl Med. 2026 Jul 27; 24(1).JT
- CONCLUSIONS: Through the cross-validation of multidimensional biophysical features, the FRAC-3D model enables high-precision preoperative prediction of MVI status. This study advances the perioperative assessment of CRLM from traditional 'static anatomical metrics' into a novel dimension of 'microenvironmental dynamic evolution', providing a robust, physics-driven tool for individualized surgical margin planning and the precise stratification of targeted neoadjuvant therapy.
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- Mitoxyperilysis-based molecular subtyping identifies SPP1+ macrophages and IL1B as critical mediators of tumor progression and immunotherapy resistance in intrahepatic cholangiocarcinoma. [Journal Article]J Transl Med. 2026 Aug 03; 24(1).JT
- CONCLUSIONS: Mitoxyperilysis-related molecular classification provides a clinically relevant framework for prognostic stratification and prediction of immunotherapeutic responsiveness in ICC. SPP1+ macrophages and IL1B represent potential therapeutic targets, providing a promising strategy for precise diagnosis and treatment of ICC.
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- The hidden effects of metabolism-disrupting agents on alcohol-related liver disease risk: an integrated epidemiological, machine learning, and network toxicology Analysis. [Journal Article]
- CONCLUSIONS: Specific MDAs demonstrated significant ALD associations through complementary approaches. Evidence suggests MDAs may function as signal disruptors within neuro-endocrine-immune networks, with pathways paralleling alcohol-induced hepatotoxicity. Findings underscore incorporating environmental assessments into ALD risk stratification and highlight needs for prospective validation and mechanistic studies.
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- Epigenetic modulation of NKG2D ligands enhances NKG2D-CAR T cell efficacy in neuroblastoma. [Journal Article]
- CONCLUSIONS: This work suggests that targeting epigenetic pathways can enhance the susceptibility of NB cells to NKG2D-CAR T cell therapy, thereby providing a potential new approach to treat high-risk NB.
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- Interpretable machine learning model for brain metastasis in breast cancer: a large-scale, multi-center study. [Multicenter Study]
- CONCLUSIONS: We developed and internally validated a accurate, clinically translatable model for predicting BM in BC using over 186,000 patients from North American and Asian cohorts. This web-based tool can assist clinicians in identifying high-risk individuals, enabling personalized management and potentially improving patient outcomes.
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- P4HA1[+] collagen-modifying fibroblasts are associated with pro-tumor niches and therapeutic vulnerabilities in colorectal cancer. [Journal Article]
- CONCLUSIONS: This study characterizes a P4HA1[+] collagen-modifying CAF subpopulation that resides within a spatially organized multicellular niche and engages distinct signaling axes to simultaneously promote angiogenesis, immune suppression, and tumor cell proliferation in CRC, highlighting its prognostic and potential therapeutic value.
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- Decoding the human milk virome: a comparative analysis of composition, colonization, and health impacts. [Journal Article]
- CONCLUSIONS: Despite limitations related to sample size and methodological variability, this study emphasizes how dietary habits, environmental exposures, and geographic location may shape the breast milk virome. Further research integrating longitudinal data from a multi-ethnic population, cohorts is essential to fully harness the diagnostic and therapeutic potential of the human milk virome.
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- Single-cell and spatial transcriptomics reveal that THBS1 induces radiation resistance in TNBC through the interaction between myCAF and TOPBP1[+] tumor cells. [Journal Article]
- CONCLUSIONS: THBS1 plays a pivotal role in mediating radioresistance in triple-negative breast cancer, positioning it as a promising therapeutic target.
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- Alveolar organoids: from model systems to applications in respiratory diseases. [Review]
- Organoid technology has emerged as a research hotspot in the biomedical field in recent years, providing important methodologies for disease modeling, drug screening, and regenerative medicine. Alveolar organoids serve as crucial models for studying respiratory diseases, and their technological evolution and application expansion reflect key advances in this field. This article systematically rev…
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- COL10A1[+] fibroblasts define rupture-prone abdominal aortic aneurysms and enable molecular risk stratification. [Journal Article]
- CONCLUSIONS: This study identifies a COL10A1[+] fibroblast-associated transcriptional state that defines a rupture-prone vascular microenvironment in abdominal aortic aneurysm. The derived COL10A1-IGFBP6 signature establishes a biologically informed framework for molecular risk stratification, complementing anatomical size-based assessment and providing a foundation for future development of mechanism-guided strategies to refine AAA risk evaluation.
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