- Enhancing accuracy and precision of arterial cerebral blood volume imaging in patients with moyamoya disease: Integration of long-labeled long-delay acquisition into DANTE-prepared multi-delay arterial spin labeling. [Journal Article]J Neurosci Methods. 2026 Sep 25; :110916. [Online ahead of print]JN
- CONCLUSIONS: The LLLD acquisition mitigates CBVa underestimation associated with prolonged ATT. Integrating an LLLD acquisition into DANTE-prepared MD-ASL improves the accuracy and precision of CBVa estimation, enabling more reliable noninvasive assessment of cerebral hemodynamics in patients with MMD.
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- Feasibility and repeatability of MEG-compatible patellar-tendon stimulator for eliciting knee-joint proprioceptive cortical responses. [Journal Article]J Neurosci Methods. 2026 Sep 25; :110915. [Online ahead of print]JN
- CONCLUSIONS: The novel stimulator is a feasible and repeatable tool for studying cortical processing of proprioceptive afference from the knee joint using MEG.
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- Exponent-based hypergraph centrality for identifying vital nodes in higher-order brain networks. [Journal Article]J Neurosci Methods. 2026 Sep 24; 437:110914. [Online ahead of print]JN
- CONCLUSIONS: HEC provides a higher-order centrality measure for ranking vital nodes in hypergraphs and a quantitative tool for retrospective SEEG-based EZ-related network analysis. The results support offline feasibility at the studied SEEG scale, but prospective validation in larger cohorts is required before use in clinical decision-making.
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- A method to quantify ligand-neuron binding in vivo. [Journal Article]J Neurosci Methods. 2026 Sep 23; 437:110911. [Online ahead of print]JN
- CONCLUSIONS: The unique organization of the RGC layer enables a robust, non-disruptive in vivo ligand-neuron binding assay that preserves native cell-surface receptors. This platform is compatible with ligandomics and can be applied to map disease-selective neuronal ligands, providing a foundation for developing targeted neuroprotective therapies for retinal disorders.
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- A novel paradigm for investigating compulsive-like behavior in rats: Excessive precautionary behavior. [Journal Article]J Neurosci Methods. 2026 Sep 23; 437:110904. [Online ahead of print]JN
- CONCLUSIONS: This exploratory study presents preliminary evidence that excessive precautionary behavior is associated with reduced engagement in alternative appetitive activities. However, this relationship remains tentative and requires replication and validation against alternative explanations, such as anxiety-related responding, perseveration, and impaired extinction. Instead of directly modeling obsessive-compulsive disorder, the proposed model may provide a complementary behavioral framework. Further multimodal studies are necessary to clarify its neurobiological basis and translational relevance.
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- A tube-restriction test: A candidate impulsivity-related assay based on nose-poke behavior dynamics. [Journal Article]J Neurosci Methods. 2026 Sep 23; 437:110912. [Online ahead of print]JN
- CONCLUSIONS: The TRT offers a rapid, training-free candidate assay for impulsivity-related phenotyping in rodents, though convergent validation against established operant benchmarks is required to confirm specificity for impulsivity rather than related constructs such as exploratory drive.
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- AI-powered rodent behavior recognition model for pain research. [Journal Article]J Neurosci Methods. 2026 Sep 23; 437:110913. [Online ahead of print]JN
- CONCLUSIONS: The AI-powered automated behavioral recognition system may offer an objective, reproducible, and scalable approach to behavioral assessment in rats, and may enhance the translational relevance of preclinical pain research and analgesic development.
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- TopoAdapter: A plug-and-play multi-hop topology adapter for MI-EEG decoding. [Journal Article]J Neurosci Methods. 2026 Sep 18; 437:110909. [Online ahead of print]JN
- CONCLUSIONS: TopoAdapter provides an explicit, ultra-lightweight spatial prior for motor EEG decoding. Positive mean changes on two motor-imagery datasets, one executed-movement dataset, and seven heterogeneous BCI IV-2a backbones support portability and a favorable cost-benefit profile, while effect magnitude remains dataset- and subject-dependent.
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- Stacked EEG spectrograms and an attention-augmented CNN-LSTM for subject-independent emotion recognition. [Journal Article]J Neurosci Methods. 2026 Sep 16; 437:110906. [Online ahead of print]JN
- CONCLUSIONS: Input-level channel integration effectively improves subject-independent EEG emotion recognition and provides a practical solution for consumer-grade EEG applications.
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- Optimized efficient channel attention-based ShuffleNet framework for EEG graph-based brain topology modeling in motor imagery tasks. [Journal Article]J Neurosci Methods. 2026 Sep 15; 437:110910. [Online ahead of print]JN
- CONCLUSIONS: The proposed ODL-BTMIT framework, leveraging the ECA-ShN model and fine-tuned with the SI-RPO algorithm, effectively enhances motor imagery classification accuracy by efficiently modeling brain connectivity and achieving stable, low-error performance.
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- A platform for repeated electric field stimulation of organotypic spinal cord slice cultures enables comparison of myelin basic protein signal across stimulation paradigms. [Journal Article]J Neurosci Methods. 2026 Sep 13; 437:110908. [Online ahead of print]JN
- CONCLUSIONS: These findings establish a method for controlled EF stimulation of OSCs and highlight its utility for systematically studying EF-mediated CNS repair mechanisms.
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- Functional brain imaging and targeted lesion studies using manganese-enhanced MRI and focused ultrasound in non-conventional model species. [Journal Article]J Neurosci Methods. 2026 Sep 13; 437:110907. [Online ahead of print]JN
- CONCLUSIONS: MEMRI identified significant manganese accumulation in the inferior lobe of fish performing a puzzle-box task, suggesting its role in object manipulation. Validation via MRI-guided HIFU thermal lesions showed that inferior lobe damage caused massive behavioral deficits, whereas cerebellar lesions had minimal impact. These results confirm the MEMRI-HIFU framework as a powerful toolkit for linking brain structure to behavior in non-model organisms.
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- Perineural co-administration of bone marrow-derived extracellular vesicle fractions and mononuclear cells via a collagen vehicle in a rat neuropathic pain model: An exploratory proof-of-concept study. [Journal Article]J Neurosci Methods. 2026 Sep 13; 437:110905. [Online ahead of print]JN
- CONCLUSIONS: Perineural co-administration of EV fractions and BMMNCs via a collagen vehicle attenuated mechanical allodynia and preserved nerve morphology. Although functional recovery was comparable to EV monotherapy and molecular findings remain exploratory (n = 1), these preliminary proof-of-concept observations support the feasibility of localized combinatorial interventions for neuropathic pain.
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- The transfer function as a method to reduce morphological models into point-neuron models. [Journal Article]J Neurosci Methods. 2026 Sep 10; 437:110899. [Online ahead of print]JN
- CONCLUSIONS: This study provides a new computational method to reduce morphological models into point-neuron models that reproduce their transfer-function properties and firing rate statistics under in vivo-like conditions.
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- Analysis of physical properties of the ulnar nerve during puncture using regional block needles. Measuring station proposal and preliminary test results. [Journal Article]J Neurosci Methods. 2026 Sep 09; 437:110903. [Online ahead of print]JN
- CONCLUSIONS: The measurement system delivered reproducible force-displacement curves and minimized artifacts from sample fixation. These preliminary ex vivo findings indicate that ulnar-nerve puncture mechanics vary with anatomical region and position along the nerve and warrant confirmation in larger donor cohorts.
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