- Response to 'Oral Colonization of the Gut May Explain the Cirrhosis Virome Signature'. [Letter]Liver Int. 2026 Oct; 46(10):e70896.LI
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- Seronegative Autoimmune Hepatitis: A Dynamic Diagnosis Requiring Standardised Reassessment. [Letter]Liver Int. 2026 Oct; 46(10):e70894.LI
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- Comment on 'Comparison of Factors Associated With 30- and 90-Day Readmission Among a Global Cohort of Patients Hospitalised With Cirrhosis'. [Letter]Liver Int. 2026 Oct; 46(10):e70859.LI
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- A Genetic Risk Variant Associated With the Risk of Primary Biliary Cholangitis Is Inherited From Neanderthals. [Journal Article]
- CONCLUSIONS: A Neanderthal-derived variant contributes to PBC risk and its frequency increased in the Bronze Age, possibly due to pathogen-driven selection. Archaic introgression overall has limited influence on PBC heritability. Functional studies are needed to elucidate the role of rs12531711.
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- Diagnostic Value and Influencing Factors of Ultrasound-Derived Fat Fraction for Quantifying MASLD in Children. [Journal Article]Liver Int. 2026 Oct; 46(10):e70883.LI
- CONCLUSIONS: UDFF is a non-invasive, accurate, and reproducible tool for quantifying paediatric hepatic steatosis. Although a systematic numerical bias exists relative to MRI-PDFF in moderate-to-severe cases, UDFF retains excellent discriminative ability and is suitable for screening, staging, and longitudinal follow-up of paediatric MASLD.
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- Applicability of Non-Invasive Eligibility Criteria for MASH Pharmacotherapy: A Multicentre Cohort Study. [Multicenter Study]Liver Int. 2026 Oct; 46(10):e70882.LI
- CONCLUSIONS: The AASLD and expert panel-derived criteria identified different real-world populations potentially suitable for MASH pharmacotherapy. In the biopsy subgroup, NIT-based eligibility classification only partly aligned with histological F2-F3 fibrosis.
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- Ultrasound-Based Skeletal Muscle Assessment for Prognostication in Cirrhosis: A Systematic Review. [Systematic Review]
- CONCLUSIONS: In our systematic review, ultrasound-based muscle measures demonstrated a broadly consistent association with mortality; although not yet fully validated, they represent a promising bedside prognostic tool. Standardization is needed before clinical implementation.
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- BBOX1 Deficiency Exacerbates Liver Fibrosis Through Carnitine Biosynthesis Disruption Rescued by Carnitine Supplementation. [Journal Article]Liver Int. 2026 Oct; 46(10):e70889.LI
- CONCLUSIONS: BBOX1 is a key regulator of liver carnitine metabolism. Its deficiency creates a pro-fibrotic state by abnormally activating the TRPC6-Ca[2+]/CAMK2B pathway. Our findings position carnitine as a protector of calcium balance in the liver and identify L-carnitine supplementation as a potential targeted treatment to slow fibrosis progression.
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- Sex Disparities in Hepatitis C Treatment Initiation: Role of Universal Access to DAA in France (ANRS FANTASIO 2). [Journal Article]
- CONCLUSIONS: In France, universal DAA access has reversed sex disparity in treatment initiation among people with chronic hepatitis C. This reversal likely reflects differences in disease progression profiles between men and women. To ensure truly equitable access to HCV care, current research should explore whether reversal or reduction of sex disparities is observed in other countries and subpopulations.
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- Multicenter Evaluation of Large Language Models Versus Hepatologists for Prognostic Prediction in Drug-Induced Liver Injury. [Multicenter Study]
- CONCLUSIONS: GPT-5.1 and Gemini-2.5 Pro showed AUROCs approaching senior hepatologists for DILI outcomes with limited accuracy and specificity. LLM-Rules demonstrated stable performance across cohorts with improved sensitivity or specificity, supporting the potential of multi-LLM approaches as clinician-supervised complementary tools.
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- Prognostic Value of Liver Stiffness in Advanced Chronic Liver Disease After Hepatitis C Virus Eradication. [Journal Article]
- CONCLUSIONS: Absolute post-treatment-LSM provides stronger prognostic information than dynamic changes from baseline. These findings support repeated post-SVR LSM assessment for risk stratification suggesting the relevance of residual liver disease in predicting liver-related outcomes.
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- Response to Letter to the Editor. [Letter]
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