- Regular physical activity is associated with lower odds of bodily pain in midlife women. [Journal Article]Menopause. 2026 Oct 13. [Online ahead of print]M
- CONCLUSIONS: Regular physical activity is independently associated with lower odds of bodily pain in midlife women. Exercise programs, in combination with MHT, may contribute to optimizing pain management in this population and warrant further prospective investigation.
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- Menopausal hormone therapy combined with antiresorptive therapy for skeletal outcomes in postmenopausal women: a systematic review and network meta-analysis of randomized controlled trials. [Journal Article]Menopause. 2026 Oct 13. [Online ahead of print]M
- CONCLUSIONS: In postmenopausal women, systemic MHT, bisphosphonate therapy, and their combination improved BMD compared with control. Combination MHT plus bisphosphonate therapy showed the most favorable hip-region BMD profile; however, current evidence is insufficient to establish superior fracture prevention or long-term safety.
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- Premature menopause and risk of type 2 diabetes among postmenopausal women: findings from the Women's Health Initiative. [Journal Article]Menopause. 2026 Oct 13. [Online ahead of print]M
- CONCLUSIONS: Premature menopause was modestly associated with an increased T2D risk; this association varied by HT use and was partially mediated by BMI.
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- Trends of menopausal hormone therapy across Canadian provinces in 2018-2023. [Journal Article]Menopause. 2026 Oct 13. [Online ahead of print]M
- CONCLUSIONS: MHT use in Canada is increasing but remains modest and variable across formulations and provinces. Markedly higher use of MHT in Quebec may be partly explained by a more comprehensive drug coverage. Our findings highlight gaps in uptake of guideline-recommended therapy and provide a foundation for future research and policy considerations.
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- Quantitative assessment of neurokinin receptor antagonists in menopausal hot flashes: a model-based meta-analysis. [Journal Article]Menopause. 2026 Oct 13. [Online ahead of print]M
- CONCLUSIONS: Fezolinetant (45 mg) and elinzanetant (120 mg) demonstrated comparable efficacy for menopausal hot flashes. Model-based indirect comparisons provided clinical context for interpreting their efficacy relative to other hormone and nonhormone therapies. This study provides quantitative evidence to inform medication selection and pharmacoeconomic evaluations in women with menopausal hot flashes.
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- Effects of adherence to a Mediterranean diet on body weight in postmenopausal women: a systematic review. [Journal Article]Menopause. 2026 Oct 13. [Online ahead of print]M
- CONCLUSIONS: The different design, limited number of studies and their small sample sizes may have limited the strength of evidence, making the detection of long-term benefits difficult. In qualitative synthesis, the included studies showed mixed findings, with no consistent superiority of MedDiet across weight, fat mass, or lean mass outcomes. MedDiet counseling alone, without explicit energy restriction or other structured weight-management strategies, should not be assumed to produce clinically meaningful reductions in body weight or fat mass.
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- The effectiveness of physical activity interventions on non-physiological symptoms of menopause: a systematic review and meta-analysis. [Journal Article]Menopause. 2026 Oct 13. [Online ahead of print]M
- CONCLUSIONS: PA may seem to improve depression, mood, and QoL in women in the MT. Both ABIs and MBIs may be beneficial, supporting the integration of PA into clinical care for menopausal women. Further high-quality trials with clearer menopause staging are needed to strengthen the evidence base.
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- Reproductive history and age at natural menopause in US women: a cross-sectional analysis of National Health and Nutrition Examination Survey 1999 to March 2020. [Journal Article]Menopause. 2026 Oct 06. [Online ahead of print]M
- CONCLUSIONS: Higher gravidity showed a small, nonconfirmatory association with later ANM at moderate exposure levels. The findings do not support a robust nonlinear relationship or a simple cumulative ovulation-sparing model.
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- Associations of psychosocial supports and stressors with cognition in midlife women. [Journal Article]Menopause. 2026 Oct 06. [Online ahead of print]M
- CONCLUSIONS: Financial and food insecurity, but not social support, perceived stress, or discrimination, were associated with poorer memory, executive function, and attention in midlife women.
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- From black box warning to wake-up call: menopausal hormone therapy prescribing patterns at a large academic medical center. [Journal Article]Menopause. 2026 Oct 06. [Online ahead of print]M
- CONCLUSIONS: MHT prescribing remained persistently low over 18 years, with significant racial disparities, lower prescribing among women with greater comorbidity burden, and differences associated with insurance coverage. These findings highlight a sustained gap between evidence-based recommendations and real-world menopause care and may suggest that both clinical and structural factors may influence access to treatment.
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- Awareness and clinical impact of the revised FDA warning on menopausal hormone therapy among Latin American physicians. REDLINC XIV. [Journal Article]Menopause. 2026 Oct 06. [Online ahead of print]M
- CONCLUSIONS: The revised FDA communication appears to have influenced Latin American physicians' views and self-reported clinical practice, promoting a more balanced view of MHT and encouraging patient education and shared decision-making. However, the increase in MHT prescribing rates was relatively modest, and overall findings should be interpreted cautiously given the cross-sectional design, self-reported nature of the data, and potential selection bias.
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- Cardiovascular risk in postmenopausal women living with HIV. [Journal Article]Menopause. 2026 Oct 06. [Online ahead of print]M
- CONCLUSIONS: Among postmenopausal women, HIV infection was independently associated with a higher prevalence of carotid plaque, despite similar cIMT values between groups. Earlier menopause appeared to act as a cardiovascular risk amplifier in WLH. Although D:A:D R10 showed a trend toward better discrimination of carotid plaque than Framingham, further studies are needed to determine the optimal cardiovascular risk stratification strategy for WLH.
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- Exploring the use of technology in menopause education for patients: a scoping review of the literature. [Journal Article]Menopause. 2026 Oct 06. [Online ahead of print]M
- CONCLUSIONS: This review identified 50 publications that described patient-facing menopause education interventions. These interventions were diverse in their teaching methods and educational content, but few studies leveraged analogue and digital technology. Future research should explore how to further leverage technology-especially digital technology such as artificial intelligence-to potentially improve menopause education.
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- Effects of neurokinin receptor antagonists on sleep disturbance in menopausal women: a systematic review and meta-analysis of randomized controlled trials. [Journal Article]Menopause. 2026 Oct 06. [Online ahead of print]M
- CONCLUSIONS: NK receptor antagonists significantly improved patient-reported sleep disturbance among perimenopausal and postmenopausal women with moderate to severe VMS. These findings support NK receptor antagonists as a promising nonhormone treatment option for VMS-associated sleep disturbance, although the magnitude of benefit should be interpreted cautiously because of substantial heterogeneity and low-certainty evidence.
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- Early menopause as a female-specific prognostic marker after acute coronary syndrome in women aged 60 years or younger: a real-world multicenter registry analysis. [Journal Article]Menopause. 2026 Oct 06. [Online ahead of print]M
- CONCLUSIONS: Menopause before age 45 years identified a higher risk post ACS phenotype. Findings extend incident risk evidence into secondary prevention and support routine recording of menopausal age; causality cannot be inferred.
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