(Neuroimmunomodulation[TA])
1,301 results
  • Towards a Cortical Framework of Neuroimmune Representation: The Insular Cortex at the Brain-Immune Interface. [Review]
    Neuroimmunomodulation. 2026 Sep 24; :1. [Online ahead of print]Bihorac J, Hadamitzky MN
  • CONCLUSIONS: Beyond its role in bidirectional neuroimmune regulation, the insular cortex has been proposed to function as a cortical hub for encoding immune-state representations.Resolving where and how the brain encodes peripheral immune states will not only illuminate how central dysregulation contributes to disease, but may reveal new therapeutic targets in which experiential and cognitive variables become tractable levers for immune intervention.
  • Extracellular Matrix-Mediated Neuroendocrine Control of the Thymus. [Review]
    Neuroimmunomodulation. 2026; 33(1):304-314.Brito-Moreira J, Herculano EA, Savino WN
  • CONCLUSIONS: A key, yet underexplored, component of the thymic microenvironment is the extracellular matrix (ECM). It is very clear today that ECM is not a passive scaffold but a dynamic structure that presents critical signals for thymocyte migration, proliferation, and selection. This review synthesizes current evidence to propose a novel paradigm: the thymic ECM acts as a key mediator of neuroendocrine control. We explore how specific ECM molecules, such as laminins, collagens, and fibronectin, expressed by TECs and other microenvironmental cells, can be modulated by neuroendocrine ligands.Theses ECM modulations directly impact the presentation of key receptors, such as integrins, thereby influencing the critical crosstalk between a given thymic niche and developing lymphocytes. By delineating the ECM-mediated mechanisms, this review aimed to provide a more holistic understanding of how neuroendocrine factors govern thymic physiology, with implications for aging, stress-related immunosenescence, and therapeutic strategies aimed at thymic regeneration.
  • The Participation of Prolactin in the Immunopathology of Experimental Pulmonary Tuberculosis. [Journal Article]
    Neuroimmunomodulation. 2026; 33(1):288-299.Mata-Espinosa DA, Quintero-Bustos G, … Hernández-Pando RN
  • CONCLUSIONS: Prolactin and its receptors appear to contribute to immune activation during pulmonary tuberculosis, particularly in the early stages of infection. Prolactin administration during late active disease reactivates immune protection. Although we do not demonstrate the mechanisms underlying these observations, these results could serve as a basis for expanding future experimental research.
  • A Comprehensive Review of Worldwide Case Series of Neurocysticercosis and Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. [Review]
    Neuroimmunomodulation. 2026; 33(1):225-235.Martínez-Juárez IE, Philibert-Rosas S, … Sotelo JN
  • CONCLUSIONS: A literature search was conducted in PubMed, Scopus, and ScienceDirect focusing on publications describing epilepsy due to NCC with HS. Twenty-three original articles, identified through 2023, were retrieved from Brazil, Ecuador, India, Mexico, and Korea. The proposed relationships between NCC and HS include incidental coexistence, NCC as an initial precipitating injury, and the presence of a third variable. While multiple hypotheses have been discussed and reported cases compiled, the precise nature of this association remains unresolved.Although the mechanisms underlying the relationship between NCC and HS are not fully elucidated, evidence supports their coexistence in patients with epilepsy. Recognition of this association is important for clinical evaluation and may guide future research on pathogenesis and management.