- Prognostic Value of Intraoperative Desmopressin Test for Long-Term Remission in Cushing's Disease: A Prospective Cohort Study. [Journal Article]Neurosurgery. 2026 Oct 05. [Online ahead of print]N
- CONCLUSIONS: The intraoperative desmopressin test is a powerful real-time predictor of long-term surgical outcome. A 15-minute ACTH response ratio ≥110% provides a critical intraoperative threshold that may guide surgical strategy and postoperative management.
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- In-Transit Deterioration and Hydrocephalus Development During Interhospital Transfer in Aneurysmal Subarachnoid Hemorrhage. [Journal Article]Neurosurgery. 2026 Oct 05. [Online ahead of print]N
- CONCLUSIONS: The transfer interval in aSAH represents a clinically vulnerable phase rather than a passive delay. Paired clinical and imaging data identify in-transit deterioration and hydrocephalus development as associations that warrant prospective investigation and may inform standardized regional transfer pathways; they do not establish intervention targets.
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- Tiny (≤3 mm) Unruptured Intracranial Aneurysms: A 13-Year Contemporary Insight on Treatment Safety From a Multicenter Registry. [Journal Article]Neurosurgery. 2026 Oct 05. [Online ahead of print]N
- CONCLUSIONS: Treatment of tiny unruptured aneurysms remains common despite very low rupture risk. Procedural risks are low and comparable with slightly larger aneurysms. Treatment decisions should integrate both rupture risk and procedural safety, with anterior communicating artery or posterior communicating artery locations and unfavorable baseline functional status representing higher-risk features. When indicated, stent-assisted coiling was independently associated with higher intraoperative complication risk relative to clipping in this cohort.
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- Sex-Based Variation in Neurosurgical Practice Patterns and Patient Characteristics. [Journal Article]Neurosurgery. 2026 Oct 05. [Online ahead of print]N
- CONCLUSIONS: Sex-based Medicare reimbursement differences in neurosurgery seem to arise from differences in procedural volume, subspecialization, and patient complexity.
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- The Kuopio Idiopathic Normal Pressure Hydrocephalus Protocol Revisited: The Predictive Value of Cerebrospinal Fluid Tap Test. [Journal Article]Neurosurgery. 2026 Oct 02. [Online ahead of print]N
- CONCLUSIONS: CSF-TT is associated with shunt outcomes when assessed with GBS. Strict reliance on CSF-TT thresholds may inappropriately exclude patients who could benefit from shunt surgery.
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- Impact of Air Bubbles on Cerebrospinal Fluid Drainage in Ventriculoperitoneal Shunts: An Experimental Validation. [Journal Article]Neurosurgery. 2026 Oct 02. [Online ahead of print]N
- CONCLUSIONS: Air bubbles entrapped in VP shunts have the capability of obstructing CSF flow, more so as bubble number increases. Careful purging of the shunt system at implantation surgery may help prevent airlock issues.
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- Neural Regeneration After Supercharged End-to-Side Nerve Transfer: Which Way to Go? [Journal Article]Neurosurgery. 2026 Oct 02. [Online ahead of print]N
- CONCLUSIONS: These results represent the stages of donor axon regeneration after SETS NT. Although early regeneration extended bidirectionally in intact and regenerating nerves, long-term outcomes favored regeneration directionally toward an end organ in the latter by reduction of proximal projections. In addition to robust axonal ingrowth, SETS NT exhibited a nonsignificant reduced distal regeneration capacity compared with end-to-end coaptation. Consequently, it might represent a considerable alternative while simultaneously preserving native nerve regeneration capacities, warranting further investigation to validate these findings in a clinical context.
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- Time Course of Elbow Flexion Recovery Following Brachial Plexus Injury and Peripheral Nerve Reconstruction. [Journal Article]Neurosurgery. 2026 Apr 30. [Online ahead of print]N
- CONCLUSIONS: In this retrospective study of patients with BPI and EF deficits, longitudinal data such as EF Medical Research Council Scale for Muscle Strength and biceps electromyographies are useful clinical predictors for recovery. Although the treatment of BPI remains highly individualized, these data suggest 2 key metrics, neurophysiological recovery and the 5-month benchmark, to better counsel patients on the time course of their recovery. Importantly, different injury types and reconstructions did recover at different rates, and this must be taken into consideration when attempting to predict ultimate recovery or need for reconstruction.
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- Long-Term Outcomes of Endoscopic Endonasal Resection for Tuberculum Sella Meningiomas. [Journal Article]Neurosurgery. 2026 Oct 01. [Online ahead of print]N
- CONCLUSIONS: EEA is a safe and effective primary treatment for TSMs, yielding a high Simpson Grade 1 rate, resultantly low long-term recurrence rate, and improved visual outcomes.
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- Safety of Staged Bilateral MRgFUS Thalamotomy: Associations Between Lesion Characteristics, Stereotactic Coordinates, and Adverse Events. [Journal Article]Neurosurgery. 2026 Oct 01. [Online ahead of print]N
- CONCLUSIONS: AE persistence after the second session was volume-dependent, with rates comparable to the first session at smaller lesion volumes but elevated at larger volumes. Posterior lesion positioning was independently associated with mouth numbness and speech deficits, supporting anterior targeting adjustments for contralateral procedures. These findings suggest that lesion volume constraint combined with anterior positioning may optimize the safety profile of staged bilateral MRgFUS thalamotomy, although prospective validation is needed to establish definitive volume thresholds.
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- Utility of Percutaneous Meckel's Cave Methylprednisolone/Bupivacaine Injection for Patients With Refractory Trigeminal Neuralgia With Concomitant Continuous Pain: Corrigendum. [Journal Article]Neurosurgery. 2026 Oct 01. [Online ahead of print]N
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- Ultra-Rapid β2-Transferrin Lateral Flow Immunoassay Enables Accurate Point-of-Care Detection of Cerebrospinal Fluid. [Journal Article]Neurosurgery. 2026 Sep 30. [Online ahead of print]N
- CONCLUSIONS: This feasibility study supports the potential utility of a rapid β2-transferrin LFA as a simple point-of-care assay for CSF detection. Larger prospective validation in real-world rhinorrhea, otorrhea, wound-drainage, and postoperative leak samples is warranted.
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- Is Preoperative Cervical Kyphosis a Fixed Structural Deformity in Compressive Myelopathy? A Longitudinal Dynamic Radiographs Analysis. [Journal Article]Neurosurgery. 2026 Sep 30. [Online ahead of print]N
- CONCLUSIONS: Mild preoperative kyphosis of the cervical spine on neutral position may represent a potentially reversible condition rather than a fixed deformity. This aspect warrants careful consideration when selecting a posterior decompressive surgery.
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- Letter: The Power of the Pen and "Standard of Care". [Letter]Neurosurgery. 2026 Sep 30. [Online ahead of print]N
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- Commentary: Direct Oral Anticoagulant Plus Single Versus Dual Antiplatelet Therapy After Carotid Artery Stenting: A Multicenter Propensity-Matched Cohort Study. [Journal Article]Neurosurgery. 2026 Sep 25. [Online ahead of print]N
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