- Axial Length Stabilization and Scleral Curvature Changes following Repeated Low-level Red-light Therapy in Children with High Myopia. [Journal Article]Ophthalmic Res. 2026 Oct 22. [Online ahead of print]OR
- CONCLUSIONS: RLRL therapy was associated with AL stabilization in highly myopic eyes. Although apparent scleral curvature change was observed, it was a post hoc analysis in a small number of eyes and its association with choroidal thickness and the shortening of the AL needs further investigation.
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- Incremental Predictive Value of Month-1 OCT and OCT Angiography for Residual Exudative Activity After Anti-VEGF Loading in Treatment-Naive Neovascular Age-Related Macular Degeneration. [Journal Article]Ophthalmic Res. 2026 Oct 15; :1. [Online ahead of print]OR
- CONCLUSIONS: Month-1 structural OCT substantially improved prediction of month-3 residual exudative activity beyond baseline OCT alone, whereas OCTA-derived MNV area contributed modest additional discrimination. These findings identify the first post-treatment imaging visit as an informative point for short-term anatomical risk assessment, but external validation is required before clinical application.
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- Increased Pupil Constriction Latency in Immunoglobulin G4-related Ophthalmic Disease. [Journal Article]Ophthalmic Res. 2026 Oct 12; :1. [Online ahead of print]OR
- CONCLUSIONS: IgG4-ROD eyes exhibit prolonged pupil constriction latency, suggesting subclinical involvement of the pupillary light reflex pathway. Virtual reality-based infrared pupillometry may serve as a useful non-invasive tool for detecting neural or autonomic dysfunction in IgG4-ROD.
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- A Systematic Quality Assessment of Online Resources on Keratoconus using the Modified Ensuring Quality Information for Patients (mEQIP). [Journal Article]Ophthalmic Res. 2026 Oct 07; :1. [Online ahead of print]OR
- CONCLUSIONS: Overall, this study indicates moderate quality of online information regarding keratoconus and underscores the need for improvements of online health resources.
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- Ocular Manifestations and Management of Graft-versus-Host Disease: A Comprehensive Review. [Review]
- CONCLUSIONS: While the ocular surface is primarily affected, oGVHD can also impact other eye components, leading to debilitating symptoms. The diagnosis of oGVHD poses significant challenges due to its relapsing and remitting nature, complicating effective treatment strategies. Prompt identification of ocular manifestations is essential, as early intervention can prevent vision-threatening complications and improve patient outcomes. As research continues to evolve, understanding the underlying mechanisms and exploring innovative therapeutic options will be crucial in managing this complex condition effectively.This review highlights the importance of heightened awareness among healthcare providers regarding the ocular signs of GVHD, advocating for timely diagnosis and personalised treatment approaches.
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- Changes in Beta Parapapillary Atrophy in Primary Angle-Closure Suspect: A 5-Year Follow-Up Study. [Journal Article]Ophthalmic Res. 2026 Aug 26; :1. [Online ahead of print]OR
- CONCLUSIONS: The morphology parameters of β-PPA were enlarged in eyes with PACS during the 5-year follow-up period. The presence of β-PPA enlargement was associated with a longer AL and larger VCDR at baseline.
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- Diagnostic Performance of Deep Learning Using Retinal Images for Detection of Chronic Kidney Disease: A Systematic Review and Meta-Analysis. [Systematic Review]Ophthalmic Res. 2026; 69(1):286-300.OR
- CONCLUSIONS: Deep learning based on retinal images had moderate diagnostic performance for detection of CKD. Relatively high sensitivity and modest specificity suggest that deep learning is more effective for ruling out CKD than for confirming the diagnosis that deep learning is more effective for ruling out CKD than for confirming the diagnosis. Deep learning-based retinal analysis may therefore serve as a supportive, noninvasive screening or triage tool but should not replace established diagnostic methods for CKD.
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- Patient and Neighborhood Factors Influencing Participation in a Personalized Glaucoma Coaching Program. [Journal Article]
- CONCLUSIONS: Among SEE pilot program participants, acceptability barriers and awareness facilitators were the most frequently cited. There were ADI differences for barriers and facilitators. Neighborhood factors should be considered when implementing glaucoma coaching programs, as program interaction varies by these characteristics. The SEE pilot program facilitated glaucoma medication adherence through educational resources and adherence monitoring tools.
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- Erratum. [Published Erratum]
- In the article by Feng et al. entitled "Postoperative Outcomes and Prognostic Factors of High Myopia-Epiretinal Membrane Associated with Retinoschisis after Vitrectomy" [Ophthalmic Res. 2025;68:275-284; https://doi.org/10.1159/000544928], there is an error where the funding number was incorrectly listed as 8240040319. The correct National Natural Science Foundation of China (NSFC) Grant No. shoul…
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- Construction and Applications of Knowledge Graphs in Ophthalmology. [Review]
- CONCLUSIONS: This paper reviews the methodologies for constructing medical KGs and highlights their applications in ophthalmology, with particular emphasis on the integration of ophthalmic KGs with medical imaging and large language models. Furthermore, it discusses existing challenges - ranging from privacy and regulatory constraints to high construction and maintenance costs, limited fusion of imaging and multimodal data, insufficient coverage of rare eye diseases and insufficient application in education and basic research - aiming to provide insights that promote deeper research and clinical translation of ophthalmology KGs.The integration of KGs with multimodal technologies represents a research frontier in the transformation of ophthalmic clinical practice, enabling more structured and precise diagnostic reasoning. Future research should focus on the construction of domain-specific KGs for rare ocular diseases and spearhead the development of multimodal knowledge frameworks to fill existing knowledge gaps, thereby ultimately enhancing both patient clinical outcomes and medical education.
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- The Link between Obstructive Sleep Apnea and Dry Eye Disease: Pathophysiology and Current Updates. [Review]
- CONCLUSIONS: Continuous positive airway pressure (CPAP) therapy is the standard treatment for OSA patients with both beneficial and detrimental effects. It alleviates inflammation and hypoxia while potentially exacerbating DED due to airflow leakage or retrograde air movement. Mechanical factors such as face-down sleeping positions and habitual eye rubbing enhance the risk of meibomian gland dysfunction in OSA patients. This review highlights the multifactorial etiology of OSA-related DED, highlighting the roles of systemic and ocular inflammation, lipid metabolism dysfunction, and mechanical stress.We also emphasize the need for interdisciplinary management, combining sleep medicine and ophthalmology, to optimize outcomes for OSA patients with ocular surface disorders. Future research into targeted therapies, such as modulation of the Hif/NF-κB pathways and innovative CPAP device designs, holds promise for mitigating OSA-induced ocular complications.
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- Correlations between Clinical Activity Score and Serological and Radiological Data in Treatment-naïve Ethnic Han Chinese Thyroid Eye Disease. [Journal Article]Ophthalmic Res. 2026 Jun 29; :1-14. [Online ahead of print]OR
- CONCLUSIONS: The correlation between CAS and STIR signals was generally weak, and no significant correlation was identified between CAS and serological markers. These findings suggest that orbital MRI may provide complementary information beyond clinical assessment in evaluating disease activity in Ethnic Chinese TED patients.
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- Stem Cell-Based Interventions for Retinal Ganglion Cell Protection and Regeneration in Glaucoma: A Review of Current Evidence and Future Directions. [Review]Ophthalmic Res. 2026; 69(1):237-251.OR
- CONCLUSIONS: Stem cell interventions have the unique potential to assist with the preservation and restoration of dysfunctional RGCs via direct cellular replacement, differential neuroprotection, and stimulation of endogenous repair mechanisms. The focus of this review is on the most contemporary innovations which utilize stem cells to preserve and regenerate RGCs, which are vitally important for sight. The review addresses some of the newer cell source and cell prep technologies, particularly those using disorganized retinal microenvironment cell preps. Retinal microenvironment cell preps have resulted in some novel microenvironment cells designed to sequester stem cell grafts, to improve stem cell microenvironment cell preps, and to augment microenvironment cell preps. Some of the major challenges are reconstructing and integrating the lost retino-tectal and retino-collateral synapses in the visual pathway and the axonal outgrowth to and targeting appropriate central visual synaptic areas.Some major challenges are safety, RGC immunochemistry and cell type diversity, and scalable cell prep technologies. This review encapsulates how stem cell biology, along with other technologies like gene editing and tissue engineering, is forming the basis for developing first-of-its-kind regenerative therapies to restore vision in glaucoma patients, based on recent preclinical studies and ongoing early-phase clinical trials.
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- Eye-Tracking Reading Patterns as Correlates of Clinical Measures in Glaucoma. [Journal Article]Ophthalmic Res. 2026; 69(1):220-235.OR
- CONCLUSIONS: SAP data had a stronger correlation to reading abnormalities compared to the OCT data. Central superior SAP damage is the most associated with abnormal reading patterns in a computer screen environment. Peripheral SAP injuries correlated with shorter saccades size.
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- A Matching-Adjusted Comparison of Faricimab and Aflibercept 8 mg in Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema. [Journal Article]
- CONCLUSIONS: This matching-adjusted NMA indicated that dual angiopoietin-2/vascular endothelial growth factor (VEGF)-A inhibition with faricimab was associated with greater retinal drying during the matched-dosing phase in patients with nAMD and DME. Early dual pathway inhibition may therefore improve outcomes beyond anti-VEGF monotherapy.
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