- The Evolution and Clinical Utility of Oral Epithelial Dysplasia Grading Systems: A Narrative Review. [Review]Oral Dis. 2026 Oct 27. [Online ahead of print]OD
- CONCLUSIONS: While the WHO system remains the gold standard, its subjectivity complicates clinical decisions. Adopting objective binary and feature-specific models offers superior clinical utility for risk stratification. Clear numerical cutoffs alongside expanded morphological features and biomarkers may influence the accuracy of predicting malignant transformation, inform clinical decision-making regarding surgical versus conservative surveillance, and optimize patient management when integrated with clinicopathological findings.
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- Diagnostic Performance of Artificial Intelligence in Detecting Periodontal Diseases Using Cone-Beam Computed Tomography: A Systematic Review. [Review]Oral Dis. 2026 Oct 27. [Online ahead of print]OD
- CONCLUSIONS: Despite limitations arising from heterogeneous methodologies and non-standardized data collection, CBCT-based AI models show considerable promise for enhancing periodontal disease diagnosis. Further high-quality, methodologically robust research is warranted to validate and optimize these approaches for clinical use.
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- Effect of Water Rinsing on Dental Biofilm pH After Exposure to Fermentable Carbohydrate: A Scoping Review. [Review]Oral Dis. 2026 Oct 22. [Online ahead of print]OD
- CONCLUSIONS: Based on a small heterogenous set of studies, it may be summarized that rinsing with ≥ 20 mL of water following FC appears to neutralize dental biofilm; its effectiveness should be further investigated as a cost-effective, accessible, dental-caries prevention strategy.
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- DNA Adducts, Chromosomal Instability, EMT, and GSTM1 in Oral Squamous Cell Carcinoma. [Journal Article]Oral Dis. 2026 Oct 22. [Online ahead of print]OD
- CONCLUSIONS: Nodal status and advanced stage were the dominant independent determinants of survival, with routine nodal assessment improving prognostic discrimination beyond stage alone. The four molecular markers tracked with disease characteristics but added no independent prognostic value, warranting replication in larger, prospective cohorts.
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- RIPK3 Promotes Gingival Fibroblast Apoptosis and Periodontal Inflammatory Injury by Impairing Mitophagy. [Journal Article]Oral Dis. 2026 Oct 21. [Online ahead of print]OD
- CONCLUSIONS: RIPK3 elevation exacerbates periodontal damage via mitophagy impairment and dual activation of apoptosis and necroptosis. RIPK3 inhibition improves mitophagy, though its direct targeting of FUNDC1 requires further validation. RIPK3 serves as a promising therapeutic candidate for periodontitis.
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- Association Between Oral Health Status at Admission and Length of Hospital Stay in the Intensive Care Unit: A Retrospective Cohort Study (2024-2025). [Journal Article]Oral Dis. 2026 Oct 19. [Online ahead of print]OD
- CONCLUSIONS: Despite a remarkably high baseline burden of oral disease at ICU admission, chronic caries experience was not independently associated with ICU LOS, which was driven primarily by ventilatory support.
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- "HALP" For Assessing Malignant Transformation Risk of Oral Potentially Malignant Disorders (OPMDs). [Letter]Oral Dis. 2026 Oct 19. [Online ahead of print]OD
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- The Association Between Oral Lichen Planus and Diabetes Mellitus: A Scoping Review of the Evidence. [Review]Oral Dis. 2026 Oct 19. [Online ahead of print]OD
- CONCLUSIONS: The OLP-DM association is consistent, biologically plausible, and extends to subclinical glycaemic dysregulation. Glycaemic assessment should be considered in patients with OLP presenting with oral or systemic features suggestive of metabolic dysregulation. Future research should prioritise longitudinal studies, intervention trials on glycaemic optimisation.
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- Association Between Oxidative Stress Biomarkers and Periodontitis in Saliva and Gingival Crevicular Fluid: A Systematic Review and Meta-Analysis. [Review]Oral Dis. 2026 Oct 19. [Online ahead of print]OD
- CONCLUSIONS: This meta-analysis supports an association between periodontitis and altered OS biomarker levels in saliva and GCF.
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- Evaluation of the Clinical Efficacy of High-Intensity Focused Ultrasound in the Treatment of Oral Leukoplakia. [Journal Article]Oral Dis. 2026 Oct 19. [Online ahead of print]OD
- CONCLUSIONS: HIFU demonstrates significant clinical efficacy in treating OLK. Postoperative reactions are localized and well-tolerated, markedly improving patients' quality of life.
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- Differential Diagnosis Performance of ChatGPT in Oral and Maxillofacial Pathology. [Journal Article]Oral Dis. 2026 Oct 19. [Online ahead of print]OD
- CONCLUSIONS: ChatGPT ranked the reference diagnosis first in fewer than half of cases, while broader differential lists more often included it. Images did not significantly improve accuracy, although heterogeneous and non-standardised visual inputs may have limited detection of multimodal effects. These findings support further investigation for hypothesis generation and educational use rather than clinical decision support or replacement of expert judgement and histopathological confirmation.
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- Effect of Pilocarpine on Salivary Flow Rate in Patients With Xerostomia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [Review]Oral Dis. 2026 Oct 19. [Online ahead of print]OD
- CONCLUSIONS: Pilocarpine improves salivary flow rate in patients with xerostomia, particularly when residual salivary gland function is preserved, with topical formulations showing more consistent evidence of efficacy. However, given the high heterogeneity, results should be interpreted cautiously.
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- Differential Expression of P53, CDKN2A, NOTCH1, and CASP8 in Oral Epithelial Dysplasia: An In Vitro Study to Explore Potential Malignant Transformation. [Journal Article]Oral Dis. 2026 Oct 19. [Online ahead of print]OD
- CONCLUSIONS: The current study illustrates that the high expression of p53, combined with low expression of CDKN2A and NOTCH1, may serve as helpful markers, providing a potential molecular complement to histopathology for predicting malignant transformation in OED.
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- The Impact of the COVID-19 Pandemic on Oral Cancer Screening: Real-World Data From Taiwan. [Journal Article]Oral Dis. 2026 Oct 19. [Online ahead of print]OD
- CONCLUSIONS: The first outbreak had the greatest impact on screening-related indicators, with findings consistent with possible delays in cancer detection. Maintaining organized screening services during public health emergencies is essential to minimize delayed cancer detection.
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- Efficacy of Physical Therapy on Maximal Mouth Opening in Patients Affected by Disc Displacement and Degenerative Temporomandibular Joint Diseases: A Systematic Review. [Review]Oral Dis. 2026 Oct 12. [Online ahead of print]OD
- CONCLUSIONS: Findings from the present systematic review showed that physiotherapy (active and passive jaw exercises, associated with relaxation techniques) might improve MMO. Further studies with uniform protocols and high-quality randomized trials are needed to validate the efficacy of multimodal treatments in arthrogenic TMD subtypes.
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