- HIF-1α deficiency impairs mandibular condylar osteochondral maturation and triggers progenitor hyperproliferation via dysregulated mTOR-cytoophidia dynamics. [Journal Article]Osteoarthritis Cartilage. 2026 Oct 29. [Online ahead of print]OC
- CONCLUSIONS: HIF-1α signaling in Osx-lineage progenitors is essential for the establishment and maturation of the mandibular condylar osteochondral unit. Beyond its established role in skeletal differentiation, HIF-1α appears to regulate progenitor proliferative behavior through mTOR-associated cytoophidia dynamics, suggesting a metabolic mechanism underlying mandibular condyle morphogenesis.
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- Sarcopenic obesity and pain sensitivity, central sensitization-related symptoms, and physical function among patients undergoing total knee arthroplasty: A cross-sectional study. [Journal Article]Osteoarthritis Cartilage. 2026 Oct 28. [Online ahead of print]OC
- CONCLUSIONS: Differences in pain-related characteristics and physical function were observed across body composition phenotypes. Exploratory comparisons showed higher CSI-9 scores and lower affected-knee PPTs in patients with sarcopenic obesity than in those with no obesity/sarcopenia and obesity. However, the mechanisms underlying these differences remain unclear because neuropathic-like pain was not assessed. Further studies incorporating neuropathic-like pain assessment are needed to clarify associations between body composition phenotypes and pain-related characteristics.
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- Development of a Composite Pain Sensitivity Index and Its Relationships with Knee Pain Severity and Patterns in People with or at Risk for Knee Osteoarthritis: The Multicenter Osteoarthritis Study. [Journal Article]Osteoarthritis Cartilage. 2026 Oct 28. [Online ahead of print]OC
- CONCLUSIONS: A composite PSI combining QST measures of ascending (PPT/TS) and descending (CPM) nociceptive signaling had generally stronger associations than individual QST measures cross-sectionally, and to a lesser extent longitudinally. A composite PSI may provide better insights into capturing concurrent pain status than individual QST measures, whereas its predictive utility over time appears to be more pain outcome-specific.
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- Leptin drives osteoarthritis pain through sensory neuron reprogramming independent of cartilage signaling. [Journal Article]Osteoarthritis Cartilage. 2026 Oct 27. [Online ahead of print]OC
- CONCLUSIONS: In mice, leptin contributes to OA pain independently of chondrocyte-intrinsic signaling and structural disease severity. These findings identify leptin-associated neuronal programs linked to nociceptor sensitization and support further investigation of adipose-joint-sensory neuron signaling as a mediator of obesity-associated OA pain.
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- Efficacy and safety of the TRPV1 agonist RTX-GRT7039 in patients with pain associated with knee osteoarthritis: Results from a phase 3, randomised, placebo-controlled trial. [Journal Article]Osteoarthritis Cartilage. 2026 Oct 22. [Online ahead of print]OC
- CONCLUSIONS: IA RTX-GRT7039 did not demonstrate a clinically meaningful or statistically significant benefit over placebo for KOA pain relief. The safety profile of RTX-GRT7039 was consistent with previous studies.
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- Metal cations Mg[2+] and Ca[2+] are major mediators of synovial fluid protection against fatigue failure of devitalized immature bovine cartilage under cyclical compression. [Journal Article]Osteoarthritis Cartilage. 2026 Oct 18. [Online ahead of print]OC
- CONCLUSIONS: Mg[2+] and Ca[2+] are the major mediators of SF protection against cartilage fatigue failure under cyclical compressive loading (E2). Chelation of metal cations abolished this protection (E3), whereas the major protein and lipid constituents of SF (BSA, γ-globulin, and SAPL), individually or in combination (E1), as well as all other SF constituents (E3), failed to reproduce it.
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- Knee arthroplasty is an effective treatment for people with overweight/obesity and painful knees, but is this the endpoint we want for our patients? [Editorial]Osteoarthritis Cartilage. 2026 Oct 18. [Online ahead of print]OC
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- Optical monitoring of inflammatory response in joint explant cultures using near infrared spectroscopy. [Journal Article]Osteoarthritis Cartilage. 2026 Oct 16. [Online ahead of print]OC
- CONCLUSIONS: This study showed that NIR spectroscopy combined with ML can detect and quantify OA-related spectral signatures in explant media, thereby demonstrating its potential as a non-destructive and rapid method for monitoring inflammatory activity in ex vivo OA models.
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- Modeling progressive pseudorheumatoid arthropathy of childhood: Disease progression and cartilage pathology in CCN6 knockout sheep. [Journal Article]Osteoarthritis Cartilage. 2026 Oct 15. [Online ahead of print]OC
- CONCLUSIONS: These data indicate CCN6-KO sheep recapitulate clinical, histological, and molecular features of PPAC, and can be used to elucidate disease mechanisms and test therapies.
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- Development and characterization of a rat model of post-traumatic ankle osteoarthritis. [Journal Article]Osteoarthritis Cartilage. 2026 Oct 15. [Online ahead of print]OC
- CONCLUSIONS: This study sheds light on the pathological changes in synovial tissue and identifies key pathways involved in PTAOA. The findings suggest novel therapeutic targets for managing PTAOA. Additionally, the PTAOA model developed in this research can be used as a preclinical model to test potential treatments.
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- The challenge of linking tissue-based molecular clusters to osteoarthritis, a complex multi-faceted disease. [Editorial]Osteoarthritis Cartilage. 2026 Oct 15. [Online ahead of print]OC
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- Response to: 'A unicompartmental-enriched comparator in the INKA trial: Implications for the non-inferiority conclusion'. [Letter]Osteoarthritis Cartilage. 2026 Oct 13. [Online ahead of print]OC
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- Fundamentals of osteoarthritis: Biomarkers. [Review]Osteoarthritis Cartilage. 2026 Oct 10. [Online ahead of print]OC
- CONCLUSIONS: Three major advances have emerged: (1) molecular abnormalities can precede radiographic OA by years, reframing OA as a process of prolonged preclinical perturbation of innate immunity; (2) multi-omics approaches support molecular endotyping and precision medicine strategies; and (3) emerging proteomic biomarkers, exemplified by CRTAC1 and multi-protein panels, augment established biomarker classes and improve risk stratification. Continued validation will be essential for clinical and regulatory translation.
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- Osteoarthritis year in review 2026: Biomechanics. [Journal Article]Osteoarthritis Cartilage. 2026 Oct 09. [Online ahead of print]OC
- CONCLUSIONS: Over the past 12 months, evidence has strengthened links between biomechanics and symptomatic and structural osteoarthritis progression, alongside advances in real-world assessment, movement phenotyping, and personalised interventions. Large-scale and real-world biomechanical measurements are becoming increasingly feasible, and biomechanics-informed randomised controlled trials show promise for improving symptoms and slowing structural progression. Connecting scalable biomechanical assessment with clinically meaningful phenotypes and targeted interventions is a key next step toward personalised, mechanism-based osteoarthritis prevention and management.
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