- Daylight Photodynamic Therapy Alone or Combined With Transepidermal Drug Delivery Techniques for Skin Field Cancerization: An Immunohistochemical Study of Epidermal Carcinogenesis and Dermal Remodeling Markers. [Randomized Controlled Trial]
- CONCLUSIONS: A trend toward reduced vertical Ki67 expression suggests potential benefit of DL-PDT combined with microneedling and CO2 laser, and favorable changes in dermal remodeling markers were observed overall. These exploratory findings require confirmation in larger randomized studies.
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- Efficacy of Low-Dose Isotretinoin Combined With ALA-Photodynamic Therapy for Perifolliculitis Capitis Abscedens et Suffodiens: A Retrospective Study. [Journal Article]Photodermatol Photoimmunol Photomed. 2026 Nov; 42(6):e70128.PP
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- Clinical Efficacy of 5-Aminolevulinic Acid Photodynamic Therapy Combined With Interferon Spray in Treating Common and Plantar Warts. [Randomized Controlled Trial]
- CONCLUSIONS: 5-ALA-PDT combined with rhIFN-α2b spray exhibited superior clinical efficacy in treating common and plantar warts, significantly improving treatment efficacy, reducing medium-term recurrence, and demonstrating good safety and tolerability.
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- Beyond UV: Visible Light and Pigmentation. [Review]Photodermatol Photoimmunol Photomed. 2026 Sep; 42(5):e70125.PP
- CONCLUSIONS: This review establishes VL as a clinically significant driver of melasma and PIH pathogenesis. Standardising VL photoprotection metrics and integrating these into sunscreen development is essential. Incorporating VL protective strategies into treatment recommendations is critical to improving outcomes, particularly in darker skin individuals where disease burden is greatest and treatment most challenging.
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- Comparative Efficacy and Safety of Needling-Based Therapies Versus Ablative Fractional Lasers for Scar Management: A Systematic Review and an Exploratory Meta-Analysis. [Systematic Review]Photodermatol Photoimmunol Photomed. 2026 Sep; 42(5):e70121.PP
- CONCLUSIONS: Available evidence suggests that both modalities can improve scars. Ablative fractional lasers may offer greater efficacy, whereas needling-based therapies may provide better tolerability and pigment safety. These conclusions should be interpreted cautiously because of clinical heterogeneity and the sensitivity of the exploratory pooled estimate to individual studies. Treatment selection should remain individualized according to scar type, patient priorities, and acceptable downtime.
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- Photothermal-Activated Platelet-Rich Plasma Versus Conventional Platelet-Rich Plasma for Melasma: A Split-Face, Double-Blind Randomized Controlled Trial. [Randomized Controlled Trial]
- CONCLUSIONS: PT-PRP and C-PRP produced comparable clinical improvement, but PT-PRP achieved greater objective melanin reduction at week 12. PT-PRP may represent a safe alternative treatment for melasma.
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- Sun Exposure and Photoprotection Knowledge, Habits, and Attitudes Among Spanish Military Personnel. [Journal Article]
- CONCLUSIONS: Spanish military personnel demonstrate adequate knowledge and positive attitudes toward photoprotection but insufficient protective practices, particularly outside the occupational setting. These findings highlight the need to strengthen health education and integrate photoprotection into military training and operational environments.
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- Evaluating the Efficacy of Sunscreen Formulas in Reducing UV Filter Permeation Into the Stratum Corneum via In Vivo Confocal Raman Spectroscopy: Insights and Applications for Practical Suncare Product Design. [Journal Article]
- CONCLUSIONS: The permeation of different single UV filters by confocal Raman spectroscopy suggested that HMS exhibited the deepest permeation. Subsequently, by designing a series of distinct formulations, we identified the formulation components that influence the permeation of HMS. Based on the study findings, a practical formulation was designed that not only minimizes the permeation of the UV filter (HMS) but also does not inhibit the permeation of the skin-brightening agent. This study may serve as a reference for subsequent investigations into the permeation of UV filters.
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- Natural Agents for Preventing Skin Damage Induced by Visible Light: A Systematic Review of Preclinical and Clinical Evidence. [Systematic Review]
- CONCLUSIONS: Overall, available evidence supports a protective role for selected natural compounds against VL-induced skin damage, particularly through antioxidant and anti-inflammatory mechanisms, with the strongest clinical evidence focusing on natural sources of polyphenols. Nevertheless, this review highlights the need for standardized phototesting protocols and well-designed clinical trials. Future research should focus on comparative efficacy, long-term safety, and integration of natural compounds into combined photoprotection strategies tailored to different skin phototypes.
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- Fixed Eruption Induced by Sunlight: A Case Report. [Journal Article]Photodermatol Photoimmunol Photomed. 2026 Sep; 42(5):e70118.PP
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- Home Phototherapy for Psoriasis: Evidence and Implementation. [Review]Photodermatol Photoimmunol Photomed. 2026 Sep; 42(5):e70117.PP
- CONCLUSIONS: Home phototherapy is safe and effective for appropriately selected patients with plaque or guttate psoriasis and represents an underutilized, cost-effective alternative to office-based care. This review identifies three gaps that must be addressed to realize its potential: absence of long-term UV exposure and skin cancer data, equity barriers that may paradoxically limit access for the patients who stand to benefit most, and uncharacterized safety risks of over-the-counter devices. Closing these gaps through prospective safety studies, equity-centered implementation, and regulatory oversight will be essential to establishing home phototherapy as a widely accessible, evidence-based standard of care.
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- Comment on "UV Protection Habits and Preferences in Patients With Distinct Cutaneous Immune-Mediated Inflammatory Diseases". [Letter]Photodermatol Photoimmunol Photomed. 2026 Sep; 42(5):e70114.PP
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