- In Vitro Stability and Pharmacokinetic Evaluation of 12 Compounds in Qingzhuan Dark Tea in Rat Models. [Journal Article]Phytochem Anal. 2026 Oct 05. [Online ahead of print]PA
- CONCLUSIONS: The integrated stability and pharmacokinetic evaluation establishes a link between physicochemical stability and biological disposition of QDT polyphenols, providing a scientific basis for QDT storage optimization, quality control, formulation development, and functional application.
- Publisher Full Text (DOI)
- Construction and Application of an Integrated "Chemical-Biological" Dual-Core Quality Evaluation System for Salvia miltiorrhiza. [Journal Article]Phytochem Anal. 2026 Oct 02. [Online ahead of print]PA
- CONCLUSIONS: The integration of chemical profiling with a standardized cell-based relative potency assay enabled multidimensional assessment of S. miltiorrhiza quality by simultaneously characterizing batch composition, biological response, and their concordance. This approach provides a practical basis for identifying quality variations that may not be captured by chemical analysis alone and supports the development of more comprehensive quality-evaluation strategies for botanical drugs.
- Publisher Full Text (DOI)
- Comparative Comprehension on the Multioriginated Chinese Herb Murrayae Folium et Cacumen: From Chemical Compositions to Pharmacological Activities. [Journal Article]Phytochem Anal. 2026 Sep 22. [Online ahead of print]PA
- CONCLUSIONS: ME and MP presented similarity in potency against inflammation and oxidation, but with differences in pharmacological mechanisms due to their difference in chemistry.
- Publisher Full Text (DOI)
- UHPLC-MS/MS-Based Quantification of 14 Renshen Guben Oral Liquid-Related Constituents in Cancer Patients With Neutropenia. [Journal Article]Phytochem Anal. 2026 Sep 16. [Online ahead of print]PA
- CONCLUSIONS: G-Rb1, G-CK, and PAE were the major quantifiable circulating RSGB-related constituents within the early sampling window, and their concentrations showed exploratory associations with ANC change. These findings provide complementary in vivo evidence for evaluating RSGB-related constituents.
- Publisher Full Text (DOI)
- Can Herbal Supplement Be a Suitable Alternative of Ferrous Iron Oral Therapy to Bypass Gastrointestinal Side Effects. [Review]Phytochem Anal. 2026 Aug 25. [Online ahead of print]PA
- CONCLUSIONS: Research limitations include the need for mechanistic studies on gut microbiota interactions, a lack of long-term data, and a lack of studies on dose optimization. By filling these gaps, standardized, optimized herbal formulations and carefully planned clinical trials may provide herbal supplements as safe palatable substitutes or additions to oral ferrous treatment.
- Publisher Full Text (DOI)
- LC-MS-Guided Identification of Bioactive Constituents in Qingfei Jiedu Huatan Formula Reveals Ginsenoside Rb1 as an Endothelial Barrier-Protective Compound Targeting PAI-1 in Pneumonia. [Journal Article]Phytochem Anal. 2026 Aug 22. [Online ahead of print]PA
- CONCLUSIONS: QJHF ameliorates inflammatory lung injury in pneumonia mice by preserving the pulmonary vascular endothelial barrier. This effect is at least partly mediated by G-Rb1, which targets and suppresses PAI-1, thereby restoring VE-cadherin-mediated endothelial junction integrity.
- Publisher Full Text (DOI)
- Phytochemical Diversity and Evolving Strategies for the Quality Evaluation of Agarwood. [Review]Phytochem Anal. 2026 Oct; 37(7):879-909.PA
- CONCLUSIONS: This review documents recent advancements concerning the chemical compositions, analytical strategies, and pharmacological activities of agarwood. Challenges remain in mechanisms, structure-activity relationships, and compositional variation, hindering standardization. It will be essential for future work to deepen mechanistic insights and to identify key quality markers, thereby advancing the fields of quality control and translational research for agarwood.
- Publisher Full Text (DOI)
- Hyperspectral Camera Imaging Tandem With HPLC-UV-ELSD Determination and Cell Bioassay for Geographical Discrimination and Quality Consistency Evaluation of Anoectochilus roxburghii. [Journal Article]Phytochem Anal. 2026 Oct; 37(7):969-979.PA
- CONCLUSIONS: This study presents a novel HCI-Mamba framework designed for the rapid, nondestructive, and multicomponent quality assessment of AR. The proposed strategy offers a high-throughput solution for AR quality control while providing a methodological framework applicable to other complex herbal medicines.
- Publisher Full Text (DOI)
- Advances in Exosome-Based Therapy for Cardiovascular Disease: Traditional Chinese Medicine Offering New Avenues for Exosome Functionalization. [Review]Phytochem Anal. 2026 Oct; 37(7):936-956.PA
- CONCLUSIONS: Collectively, exosome-based systems hold great promise for CVD therapy, and TCM provides novel strategies for exosomal functionalization, which substantially enhances exosomal-mediated therapeutic efficacy for CVDs.
- Publisher Full Text (DOI)
- Plant-Derived Extracellular Vesicles (PDEVs): A Natural Nanoplatform Reshaping the Therapeutic Potential of Medicinal and Edible Plants. [Review]Phytochem Anal. 2026 Oct; 37(7):910-935.PA
- CONCLUSIONS: PDEVs, as a highly promising natural nanodelivery platform, can effectively address many obstacles faced by traditional plant-derived compounds. Although considerable challenges remain, ongoing research underscores the potential of PDEVs to open up new and transformative therapeutic applications for the development and utilization of medicinal and edible plants.
- Publisher Full Text (DOI)
- The Binding Ability of Aloe-Emodin to Free l-Cysteine on Hepatic Protein-Induced Hepatocyte Toxicity. [Journal Article]Phytochem Anal. 2026 Oct; 37(7):957-968.PA
- CONCLUSIONS: This study demonstrates that hepatotoxicity of AE is directly associated with the formation of covalent adducts targeting l-cysteine residues, providing a critical theoretical foundation for safety evaluation and clinical application of AE-containing herbs.
- Publisher Full Text (DOI)
- Antifibrotic Effects of Yi-Qi-Jian-Pi-Xiao-Yu Formula in Kidney via HIF1A-Driven M1 Macrophage Polarization. [Journal Article]Phytochem Anal. 2026 Aug; 37(6):813-825.PA
- CONCLUSIONS: YQJPXY alleviates RF by attenuating HIF1A-mediated M1 macrophage polarization, providing a potential therapeutic approach for CKD.
- PMC Free PDF
- Recent Advances on the Chemical Compositions, Biological Activities, and Applications of Ziziphi Spinosae Semen: From Traditional Treasures to Modern Medical Stars. [Review]Phytochem Anal. 2026 Aug; 37(6):795-812.PA
- CONCLUSIONS: ZSS possesses abundant bioactive compounds and exerts prominent pharmacological activities. It holds great value in chronic disease prevention and treatment, and has been developed into various functional products. Further research is required to realize intensive and rational utilization of ZSS resources.
- PMC Free PDF
- Configurational Isomer Differentiation Between 20(S)- and 20(R)-Ginsenosides in Red Ginseng via Applying [Cu[II](l-Phe)2-H][+] to Post-Column Infusion LC-MS/MS. [Journal Article]Phytochem Anal. 2026 Aug; 37(6):856-874.PA
- CONCLUSIONS: In summary, the proposed strategy combined the complexation driven by [Cu[II](l-Phe)2-H][+] with PCI-LC-ER-MS enables the differentiation of 20(R)- and 20(S)-configurational ginsenoside isomers in complicated matrices.
- PMC Free PDF
- Integrating 3D Chromatography With Orbitrap Mass Spectrometry to Profile the Chemical Constituents in JTTZ Formula and Investigate Plasma Pharmacokinetic Changes in Obese Rats. [Journal Article]
- CONCLUSIONS: The results show that the pathological state caused by a HFD changed the plasma pharmacokinetics of jatrorrhizine, mangiferin, and timosaponin BII in JTTZ, providing drug exposure evidence for the involvement of JTTZ in early diabetes intervention. The stepwise pipeline for the "offline 3D chromatography-DDA acquisition method with PIL-comparative pharmacokinetic study" in the case study of JTTZ has the potential to reveal the exposure profile of other CMFs, from compound identification to pharmacokinetic analysis.
- PMC Free PDF