- TIMS Techniques for Measuring Strontium Isotope Ratios in Apatite Grains and Application to Igneous Rock Petrology. [Journal Article]
- CONCLUSIONS: The proposed TIMS-based method for Sr isotope analysis in apatite grains provides a potential approach for investigating the initial Sr isotopic compositions of granitoid magmatic systems. This approach represents a cost-effective and time-efficient alternative to traditional whole-rock analyses, with strong potential for large-scale isotopic applications in orogenic terrains.
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- Long-Term Performance and Bulk-Isotope Effects in Methane Clumped-Isotope Measurements Using a 253 Ultra HR-IRMS. [Journal Article]
- CONCLUSIONS: The calibration framework established for methane clumped-isotope measurements with the Science Tokyo 253 Ultra HR-IRMS remained stable and applicable over multiple analytical campaigns. Validation measurements and interlaboratory comparisons demonstrated consistent results across a broad range of methane bulk-isotope compositions, without the need for campaign-specific or additional bulk-isotope-dependent corrections, with δD values extending down to -335‰.
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- Effects of Pretreatment on the Isotopic Composition of Structural Carbonate in Ray-Finned Fish Teeth. [Journal Article]
- CONCLUSIONS: Treatments with neutral or alkaline pancreatin solutions are recommended for the analysis of δ[13]C in carbonate within dentin. Although no method for ideal organic matter removal without changing δ[18]O values was identified, treatment with neutral pancreatin solution is recommended as the second-best option. Because of the small and consistent change in δ[18]O, it is possible to correct for δ[18]O alterations induced by pretreatment.
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- UPLC-Q-Exactive-Orbitrap-MS Identification and Network Pharmacology of Jianpixiaocuo Capsule for Acne. [Journal Article]Rapid Commun Mass Spectrom. 2026 Dec 30; 40(24).RC
- CONCLUSIONS: The Jianpixiaocuo Capsule, rich in terpenoids and flavonoids, effectively treats acne vulgaris linked to spleen-stomach damp-heat syndrome by modulating inflammation and sebum metabolism through a multicomponent, multitarget approach.
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- Appearance Energies of Fluorinated and Fluorine-Free Fragment-Ion Series Formed by Electron Ionization of 2-Fluoropyridine. [Journal Article]Rapid Commun Mass Spectrom. 2027 Jan 15; 41(1).RC
- CONCLUSIONS: The appearance energies reported here provide the first systematic data for the principal fluorinated and fluorine-free high-mass fragment ions of 2-fluoropyridine. Fluorine substitution changes the energetics of high-mass fragmentation without changing the principal fragmentation pattern.
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- Targeted and Non-Targeted Analysis of Novel and Legacy Per and Polyfluoroalkyl Substances in River Water by Direct Analysis in Real Time Mass Spectrometry. [Journal Article]Rapid Commun Mass Spectrom. 2026 Dec 30; 40(24):e70187.RC
- CONCLUSIONS: The findings of this work fill an important gap in PFAS analysis by enabling screening for many known classes of PFAS. Furthermore, this method is anticipated to be able to analyze additional classes of PFAS as future replacement chemicals are produced, allowing for a more comprehensive analysis to be completed.
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- Experimental Evaluation and Optimisation of Sealed-Tube Combustion Methods for Silicate Nitrogen Extraction. [Journal Article]
- CONCLUSIONS: For sealed tube combustion paired with continuous-flow isotope ratio mass spectrometry, lower combustion temperatures typically reduce N extraction from silicate materials. However, increasing the combustion duration at temperatures equal to or below 1000°C can reduce, and in some cases eliminate, this yield difference.
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- Unbalanced Driving Voltages in a Quadrupole Mass Filter. [Journal Article]Rapid Commun Mass Spectrom. 2026 Dec 30; 40(24):e70196.RC
- In the development of quadrupole mass spectrometers, there is a growing interest in understanding the modified first stability region under conditions of unbalanced DC and RF voltages.
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- Migration Characteristics and Mechanism of Active Components From Jieyu Anshen Granule in Different Insomnia Mouse Models. [Journal Article]Rapid Commun Mass Spectrom. 2026 Dec 30; 40(24):e70195.RC
- CONCLUSIONS: This study characterizes the in vivo migration characteristics of JYAS-G and provides insights into its multi-target anti-insomnia mechanism, while comparing the modeling differences between two common insomnia animal models. These findings provide scientific evidence for the rational clinical application and further development of JYAS-G.
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- A Metabolomics and Network Pharmacology Approach Using LC-MS to Investigate the Mechanisms of Fufang Ejiao Jiang in Treating Chemotherapy-Induced Myelosuppression. [Journal Article]Rapid Commun Mass Spectrom. 2026 Dec 30; 40(24):e70194.RC
- CONCLUSIONS: FFEJJ promotes hematopoietic recovery in MAC rats, likely by regulating endogenous metabolic disorders. Apigenin, oleanolic acid, maslinic acid, and azelaic acid are predicted to be multitarget active compounds, with PI3K-Akt signaling as a candidate pathway.
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- Development and Validation of a Stability-Indicating UPLC-PDA Method for Fruquintinib: LC-QTOF-MS/MS-Based Structural Characterization of Degradation Products and In Silico ADMET Prediction. [Journal Article]Rapid Commun Mass Spectrom. 2026 Dec 30; 40(24):e70191.RC
- CONCLUSIONS: The developed UPLC-PDA method provides a robust stability-indicating method for FRQ and enables comprehensive characterization of its degradation products. The discovery of the novel degradation product DP-2 expands current knowledge of FRQ degradation chemistry, whereas the combined analytical and in silico findings support pharmaceutical quality assessment, regulatory evaluation, and future safety investigations.
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- Calcium Isotopic Composition in Reindeer (Rangifer tarandus) Bones and Tooth Enamel: A Scalable Tool to Quantify Nursing Frequency in Past and Modern Populations? [Journal Article]
- CONCLUSIONS: While exploring past fecundity might prove difficult using this approach, these results are promising regarding the study of paleo-diet and pathology. A path for future methodological improvements to address the shortcomings of our approach is outlined. This work notably underscores the urgent need for better quantifying elemental turnover rates in bones and for more controlled environment studies, two critical steps to develop robust geochemical proxies for wildlife conservation and paleoecology.
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- Design Improvements of a High-Efficiency Cavity Ion Source for Enhanced Uranium Sensitivity and Mass Fractionation Studies Using TIMS. [Journal Article]
- CONCLUSIONS: The design improvements carried out in the CIS configuration resulted in higher analytical sensitivity and better resistance to systematic isotopic drift during uranium measurements. This established the CIS TIMS platform as an effective and high-performance analytical tool. It useful for precise actinide isotope ratio measurements relevant to nuclear safeguards, nuclear forensics, and trace isotopic analysis.
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- Influence of Geometrical Asymmetry on the Performance of a Digitally Driven Quadrupole Mass Filter. [Journal Article]Rapid Commun Mass Spectrom. 2026 Dec 15; 40(23):e70190.RC
- CONCLUSIONS: Geometrical asymmetry systematically degrades the performance of digitally driven quadrupole mass filters, while the initial pulse state introduces an additional operational parameter that influences transmission and resolving power. These findings establish practical constraints on maintaining symmetry in both rod geometry and spatial positioning, as well as on synchronizing ion injection with the driving RF pulse, and provide new insight into the interplay between higher order multipole fields and digital QMF operation.
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