Unbound Prime | Seizure

(Seizure[TA])

5,568 results

Acetazolamide in drug-resistant epilepsy: a systematic review with meta-analysis. [Journal Article]
Seizure. 2026 Oct 08; 143:119-129. [Online ahead of print]Mehta AA, Arasu SA, Lasker BRS
CONCLUSIONS: ACZ retains a measurable but selective antiseizure signal in DRE. However, limitations in decades-old reporting, considerable between-study heterogeneity, limited controlled clinical evidence, and modest sample sizes in phenotype-specific cohorts require researchers to interpret the evidence with caution. Nevertheless, ACZ's observed clinical activity, low cost, and distinct mechanism of action make it a promising candidate for prospective studies to identify responsive epilepsy types, assess the durability of benefit, and redefine its place in modern epilepsy care.
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Psychosocial correlates of seizure frequency in Functional/Dissociative Seizures (FDS): A systematic review. [Review]
Seizure. 2026 Sep 29; 143:110-118. [Online ahead of print]Lauer J, Rawlings GH, … Reuber MS
CONCLUSIONS: While FDS frequency remains clinically relevant, findings support the argument against using seizure counts as the primary marker of severity. Instead, they should be interpreted within a broader assessment of condition severity and patient wellbeing.
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Stereoelectroencephalography-based anatomo-electro-clinical subtyping reveals network-specific organization in parietal lobe epilepsy. [Journal Article]
Seizure. 2026 Oct 04; 143:99-109. [Online ahead of print]Song X, Hu T, … Li WS
CONCLUSIONS: SEEG-based subtyping reveals network-organized seizure semiology and improves the localization precision of the seizure onset zone (SOZ) in PLE.
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Epilepsy as a marker of cognitive decline in cerebral amyloid angiopathy: Evidence from a large multi-institutional cohort. [Journal Article]
Seizure. 2026 Oct 05; 143:92-98. [Online ahead of print]Khand Y, Vallamchetla SK, … Freund BS
CONCLUSIONS: Epilepsy in patients with CAA was associated with higher risk of cognitive decline. There was no difference in all-cause mortality, but the confidence interval does not exclude a clinically meaningful effect in either direction. These findings highlight patients with epilepsy as a subgroup of CAA cases with increased risk for cognitive decline. Prospective studies with validated cognitive assessments are needed to confirm this association.
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Genotype-phenotype correlations in KCNA2 related neurodevelopmental disorder: expanding the clinical and molecular spectrum. [Journal Article]
Seizure. 2026 Oct 03; 143:82-91. [Online ahead of print]Zhang J, Su S, … Zhang HS
CONCLUSIONS: This study expands the KCNA2 variant spectrum and supports a potential association between variant functional class and clinical severity. Integrating clinical data, structural modeling, and developmental expression analysis may improve understanding of KCNA2-related epilepsy and neurodevelopmental disorders.
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Initial experience of bortezomib in cryptogenic new-onset refractory status epilepticus: a case series. [Journal Article]
Seizure. 2026 Sep 21; 143:78-81. [Online ahead of print]Shivarthi T, Sriram M, … Gopinath SS
CONCLUSIONS: Bortezomib may represent a promising therapeutic option in immunotherapy-refractory NORSE. Larger prospective multicenter studies are needed to establish its efficacy, safety, and optimal timing of administration.
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Quantitative EEG in typical absence seizures: a systematic review of spectral and entropy/complexity signatures. [Review]
Seizure. 2026 Sep 29; 143:65-77. [Online ahead of print]Simedrea R, Mîndreanu R, … Login CS
CONCLUSIONS: Pre-ictal slow-band elevation and ictal entropy reduction are the most robust QEEG signatures of typical absence seizures. These remain research-grade findings: replication at the level of a usable effect-size estimate, and external validation of a treatment-response classifier, are necessary before any QEEG biomarker can enter clinical use.
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Feasibility of detecting changes in diary-based seizure cycles following antiseizure medication changes: A retrospective pilot study. [Journal Article]
Seizure. 2026 Sep 27; 143:57-64. [Online ahead of print]Reynolds A, Stirling RE, … Peterson AS
CONCLUSIONS: Despite inherent limitations, seizure diaries may be used to detect changes in seizure timing during ASM regimen changes, reinforcing their value for seizure cycle studies. Substantial challenges remain for clinical application.
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Prolonged intervals persist beyond epileptologist referral in corpus callosotomy: A referral odyssey analysis. [Journal Article]
Seizure. 2026 Sep 30; 143:51-56. [Online ahead of print]Konomatsu K, Ukishiro K, … Jin KS
CONCLUSIONS: Prolonged intervals occurred both before and after epileptologist referral, particularly during the period before comprehensive inpatient evaluation, suggesting that referral alone may be insufficient and that comprehensive inpatient evaluation may be important in streamlining the pathway to CC.
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A qualitative study of the barriers and enablers to antiseizure medication adherence in children with epilepsy. [Journal Article]
Seizure. 2026 Sep 28; 143:41-50. [Online ahead of print]Kyeremaa EAA, Stewart A, … Wright DS
CONCLUSIONS: Our findings highlight the potential determinants to antiseizure medication adherence in children with epilepsy and their carers/parents. Factors influencing adherence included child, parent and system level influences. We recommend that Healthcare professionals (HCPs) should proactively identify and address formulation-related challenges to support adherence and prioritise clear communication about treatment expectations.
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Expanding the epilepsy spectrum in primary coenzyme Q10 deficiency with COQ4 variants - Case series and literature review. [Journal Article]
Seizure. 2026 Sep 24; 143:31-38. [Online ahead of print]Hou JY, Chou IJ, … Lin KLS
CONCLUSIONS: Our findings broaden the epileptic spectrum associated with COQ4 variants and highlight the importance of early genetic testing in infants with developmental and epileptic encephalopathies, EIMFS, or IESS. The favorable corticosteroid response observed in our patient with IESS and COQ4 variants may have therapeutic implications and warrants further investigation.
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