(Semin Ophthalmol[TA])
2,161 results
  • The Clinical Significance of Polypoidal Lesion Regression in Polypoidal Choroidal Vasculopathy - A Review. [Review]
    Semin Ophthalmol. 2026 Oct 11; :1-10. [Online ahead of print]Chen JW, Hwang DK, … Chen SJSO
  • CONCLUSIONS: Achieving complete polypoidal lesion regression is a critical clinical endpoint for ensuring long-term disease stability and reducing the risk of catastrophic recurrence. It should nonetheless be regarded as one of several important endpoints - alongside visual acuity, exudative control, safety, and treatment accessibility. Rather than being universally superior, PDT-based combination therapy is best applied selectively in centers with access to ICGA and PDT, whereas optimized treat-and-extend anti-VEGF regimens and newer agents can also achieve meaningful regression and durable functional outcomes.
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  • Asymmetric Choroidal Vascular Remodeling Following Temporal Inverted Internal Limiting Membrane Flap Surgery: A Retrospective Longitudinal Study. [Journal Article]
    Semin Ophthalmol. 2026 Oct 10; :1-12. [Online ahead of print]Ozsaygili C, Bayram N, … Dinc GSO
  • CONCLUSIONS: Eyes with MH showed reduced CT and CVI preoperatively, followed by a significant postoperative increase after temporal inverted ILM flap surgery. These findings suggest that postoperative choroidal changes may not be uniformly distributed after temporal inverted ILM flap surgery. The more pronounced temporal changes in CVI may be related to surgical manipulation of the temporal ILM, although intrinsic nasal-temporal differences in choroidal structure may also contribute. These findings warrant further investigation in larger prospective studies.
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  • Comparison of Choroidal Vascularity Index Between Type 1 and Type 2 Macular Neovascularization Before and After Anti-VEGF Therapy. [Journal Article]
    Semin Ophthalmol. 2026 Sep 28; :1-8. [Online ahead of print]Remolí-Sargues L, Monferrer-Adsuara C, … Montero-Hernández JSO
  • CONCLUSIONS: No significant differences in CVI were found between type 1 and type 2 MNV at baseline or final follow-up, and longitudinal changes were comparable between subtypes. These findings do not support a predominant role of choroidal vascularity in distinguishing MNV subtypes. As retinal pigment epithelium integrity was not assessed, its potential contribution remains unclear. Larger prospective studies with standardized treatment protocols are needed to clarify the mechanisms underlying different MNV growth patterns.
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  • Longitudinal Ocular Surface Changes in Women with Polycystic Ovary Syndrome Receiving Hormonal or Ovulation-Induction Therapy: A Prospective Cohort Study. [Journal Article]
    Semin Ophthalmol. 2026 Sep 28; :1-12. [Online ahead of print]Emam MS, Sherif A, … Marrie ASO
  • CONCLUSIONS: PCOS is associated with subclinical ocular surface dysfunction and increased corneal thickness. Treatment modality was associated with differing ocular outcomes: HT use was associated with worsening dry eye parameters, while clomiphene citrate use was associated with improved tear film stability and meibomian gland integrity; this between-group divergence remained significant after adjusting for baseline values and for baseline hormonal/inflammatory covariates (all adjusted p < .001 except IOP). However, because treatment groups were not randomized and differed at baseline, these associations should not be interpreted as causal drug effects. Objective ocular surface assessment should be considered in PCOS management to guide therapy and monitor ocular health.
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  • ICL Sizing and Vault Prediction: A Systematic Review of Mathematical Models and Calculation Formulas. [Review]
    Semin Ophthalmol. 2026 Sep 09; :1-14. [Online ahead of print]Aguilar-Salazar FJ, Cano-Ortiz A, … González-Cruces TSO
  • CONCLUSIONS: Multiple nomograms and machine learning models are available for ICL sizing and vault prediction; but no single approach performed universally better across populations, devices, and clinical settings. Because measurement conditions, imaging platforms, institutional protocols, and surgeon-specific factors can all influence model performance, any chosen formula should be validated locally before routine use, and combining multiple validated nomograms may support safer clinical decision-making.
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  • Understanding Pterygium Surgery Outcomes: Revisiting Definitions of Recurrence and Postoperative Complications. [Review]
    Semin Ophthalmol. 2026 Sep 06; :1-6. [Online ahead of print]Atighehchian M, Kheirkhah A, … Zarei-Ghanavati MSO
  • CONCLUSIONS: Substantial variation exists in the literature on how recurrence and post-operative complications are defined following pterygium surgery. Establishing standardized classification systems is necessary and will enhance consistency in outcome reporting, improve clinical decision-making, and facilitate future meta-analyses and research goals.
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