Unbound Prime | Stroke

(Stroke[TA])

24,696 results

S-Nitrosylation of Endothelial FK506-Binding Protein 5 Impairs Angiogenesis via PHLPP-AKT Axis in Ischemic Stroke. [Journal Article]
Stroke. 2026 Aug 28. [Online ahead of print]Zhang XY, Xu H, … Sun XLS
CONCLUSIONS: We identify endothelial FKBP5 as a previously unrecognized regulator of poststroke vascular regeneration and establish S-nitrosylation at cysteine 339 as a molecular switch that restrains angiogenesis and functional recovery through PHLPP-dependent inhibition of AKT signaling. Targeting this modification may offer a strategy to enhance vascular repair after ischemic stroke.
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Prevalence and Clinical Relevance of Antiphospholipid Antibodies in Ischemic Stroke: A Systematic Review and Meta-Analysis. [Journal Article]
Stroke. 2026 Aug 28. [Online ahead of print]Watson NW, Bukhari S, … Bikdeli BS
CONCLUSIONS: Seropositivity for any aPL was present in nearly 1-in-5 patients with ischemic stroke and was associated with increased odds of ischemic stroke at presentation.
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Guidelines in Action: Central Poststroke Pain. [Journal Article]
Stroke. 2026 Aug 27. [Online ahead of print]Sarkar M, Lohana P, Awosika OOS
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Guidelines in Action: Care Coordination Poststroke. [Journal Article]
Stroke. 2026 Aug 27. [Online ahead of print]Schettini ATS
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Guidelines in Action: Mental Health After Stroke. [Journal Article]
Stroke. 2026 Aug 27. [Online ahead of print]Neale N, Halabi CS
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2026 Guideline for Adult Stroke Rehabilitation and Recovery: A Guideline From the American Heart Association and American Stroke Association. [Review]
Stroke. 2026 Aug 27. [Online ahead of print]Richards LG, Ifejika NL, … Peer Review CommitteeS
The "2026 Guidelines for Adult Stroke Rehabilitation and Recovery" replaces the 2016 "Guidelines for Adult Stroke Rehabilitation and Recovery." This updated guideline is intended to provide a comprehensive, up-to-date, evidence-based set of recommendations. The intended audience includes physicians, allied health professionals, and caregivers.
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Eligibility for Thrombolysis for Pediatric Acute Ischemic Stroke. [Journal Article]
Stroke. 2026 Aug 27. [Online ahead of print]Briest RC, Bhatia KD, … Andrews PIS
CONCLUSIONS: Based on current recommendations, 19% of symptomatic childhood AIS were potentially eligible for treatment with tPA, irrespective of delay to diagnosis. Selected patients with small-vessel AIS may offer an opportunity to extend the role of tPA. These observations may be relevant for optimizing pediatric stroke management strategies.
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Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial. [Journal Article]
Stroke. 2026 Aug 26. [Online ahead of print]Ge Y, Gao Y, … ENCHANTED InvestigatorsS
CONCLUSIONS: There was no evidence of effect modification by body weight on the effectiveness of low- versus standard-dose intravenous alteplase in patients with acute ischemic stroke. Low body weight predicts a poor outcome but not an increased risk of symptomatic intracerebral hemorrhage after thrombolysis treatment for acute ischemic stroke.
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Independent Association of RNF213 p.R4810K With Extracranial Carotid Artery Disease Beyond Intracranial Atherosclerosis. [Journal Article]
Stroke. 2026 Aug 26. [Online ahead of print]Takashima M, Kiyohara T, … Fukuoka Stroke Registry investigatorsS
CONCLUSIONS: The RNF213 p.R4810K variant was associated with ECAD independent of concomitant ICAD and showed a graded association with ECAD severity. Extracranial disease expression may involve modifiers distinct from those driving ICAD.
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Association Between Recent Mechanical Risk Factors for Venous Thrombosis and Young-Onset Cryptogenic Ischemic Stroke. [Journal Article]
Stroke. 2026 Aug 26. [Online ahead of print]Valančienė J, Ylikotila P, … SECRETO Study Group InvestigatorsS
CONCLUSIONS: Recent mechanical VTRFs occurring within 14 days preceding stroke contribute to the risk of young-onset CIS, particularly in younger individuals and those with a clinically relevant patent foramen ovale. This risk does not appear to be conveyed by thrombophilic factors assessed.
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Clinical Value of the New AHA Cancer-Related Ischemic Stroke Criteria. [Editorial]
Stroke. 2026 Sep; 57(9):2907-2908.Bernstein RA, Blumenreich RDS
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