Unbound Prime | The Journal of rheumatology.

(The Journal of rheumatology.[TA])

20,526 results

Juvenile Arthritis Quality of Life Questionnaire Responder Metrics in Juvenile Idiopathic Arthritis: Clarifying Health-Related Quality of Life Changes Across Treatment Eras. [Letter]
J Rheumatol. 2026 Aug 15. [Online ahead of print]Wang F, Qu HJR
Tsai et al compared 1-year health-related quality of life (HRQOL) after juvenile idiopathic arthritis (JIA) diagnosis between 2 Canadian inception cohorts recruited in 2005-2010 (ReACCh-Out) and in 2017-2023 (CAPRI).[1] Using the multidimensional Juvenile Arthritis Quality of Life Questionnaire (JAQQ), they reported improved overall HRQOL over the first year in both eras (mean total JAQQ change -…
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Phoenixin-14 May Be a Potential Limiting Neuropeptide for Exaggerated Inflammation in Familial Mediterranean Fever and Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis Syndrome: A Comparative Study. [Journal Article]
J Rheumatol. 2026 Aug 15. [Online ahead of print]Ayduran S, Kılbaş G, … Türkuçar SJR
CONCLUSIONS: PNX-14 may be part of a neuroimmune response aimed at resolving inflammation in autoinflammatory processes and could be a potential immunomodulatory biomarker. PNX-14 may be a complementary indicator reflecting inflammatory burden or the healing process.
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Dr. Tsai et al reply. [Letter]
J Rheumatol. 2026 Aug 15. [Online ahead of print]Tsai Z, Huber AM, … ReACCh-Out and CAPRI Registry InvestigatorsJR
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Multi-target Therapy with Rituximab plus Mycophenolate Mofetil versus Rituximab Monotherapy in Systemic Sclerosis-Associated Interstitial Lung Disease. [Journal Article]
J Rheumatol. 2026 Aug 15. [Online ahead of print]Goswami RP, Kotha VP, Surya MJR
CONCLUSIONS: In this real-world study, RTX plus MMF was associated with favourable longitudinal FVC% trajectories compared with RTX monotherapy in a non-randomised cohort, despite greater baseline disease severity in the MTT group. These findings support prospective evaluation of MTT particularly in high-risk patients.
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Early life exposures association with later diagnosis of spondyloarthritis: A population-based case-control study. [Journal Article]
J Rheumatol. 2026 Aug 15. [Online ahead of print]Altaffer AL, Weisman MH, … Weiss PFJR
CONCLUSIONS: Antibiotic exposure in the first year of life, particularly broad-spectrum penicillins, was associated with increased odds of SpA by age 21, supporting the hypothesis that early-life microbiome disruption may increase later SpA risk.
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Long-Term Safety and Efficacy of Dazukibart in Dermatomyositis: Combined Phase II Results From Double-Blind and Open-Label Extension Studies. [Journal Article]
J Rheumatol. 2026 Aug 15. [Online ahead of print]Vleugels RA, Peeva E, … Fiorentino DJR
CONCLUSIONS: The safety and efficacy profiles of dazukibart observed at 24 weeks were sustained through 92 weeks. (ClinicalTrials.gov: NCT03181893, NCT05192200).
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Bioelectric phase angle and appendicular skeletal muscle mass in Rheumatoid Arthritis: association with disease activity, the impact of disease and functional disability. [Journal Article]
J Rheumatol. 2026 Aug 01. [Online ahead of print]Charneca S, Costa C, … Sousa Guerreiro CJR
CONCLUSIONS: A lower PhA was associated with increased disease impact and more significant functional disability in RA patients.
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Understanding the impact of meeting performance measures on the outcomes of joint replacement in rheumatoid arthritis: a population-based study in British Columbia, Canada. [Journal Article]
J Rheumatol. 2026 Aug 01. [Online ahead of print]Barber CEH, Xie H, … Lacaille DJR
CONCLUSIONS: There were deficits in RA care identified at a population-level; however, no clear protective effect of adherence to PMs was found. Future measure development efforts should focus on measures with a greater impact on patient outcomes.
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Who Achieves Minimal and Very Low Disease Activity in Psoriatic Arthritis? An Analysis of the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry. [Journal Article]
J Rheumatol. 2026 Aug 01. [Online ahead of print]Ogdie A, Song C, … Mease PJJR
CONCLUSIONS: Despite receiving b/tsDMARD treatment for PsA, most patients did not achieve MDA or VLDA, with the most commonly unmet criteria being pain and other patient-reported outcomes. These findings indicate opportunities to improve PsA management.
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Clinical Meaningfulness and Improvement Thresholds of Myositis Core Set Measures: Association with Patient-Reported Outcomes. [Journal Article]
J Rheumatol. 2026 Aug 01. [Online ahead of print]Keret S, Silva RL, … Aggarwal RJR
CONCLUSIONS: CSMs demonstrate robust validity and responsiveness, closely aligning with patients' symptoms, function, and QoL, supporting their utility in IIM trials. We established CIDs for CSMs and TIS.
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ChatGPT and Other Large Language Models in Inflammatory Arthritis: A Systematic Review Across Clinical Tasks. [Journal Article]
J Rheumatol. 2026 Aug 01. [Online ahead of print]Adiniaev Y, Omar M, … Klang EJR
CONCLUSIONS: LLMs may support patient education, factual medication queries, and structured guideline questions when used under clinician review, but should not be used for case-based reasoning, treatment selection, or autonomous clinical decisions. None of the 18 included studies evaluated retrieval-augmented or agent-based systems, and none prospectively validated LLMs in clinical workflows. Safe integration in rheumatology will require purpose-built, knowledge-grounded systems and prospective evaluation before routine clinical use.
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