- Quality and clinical implications of AI chatbot responses to common patient questions about total knee arthroplasty: a multidimensional comparative study. [Journal Article]Knee. 2026 Oct 03; 63:104648. [Online ahead of print]KNEE
- CONCLUSIONS: AI chatbot performance for TKA FAQs is domain-dependent across quality, usability, and transparency. These findings have direct implications for orthopedic practice, particularly in preoperative patient counseling and shared decision-making in TKA.
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- Mechanisms underlying the inhibition of chondrocyte apoptosis and inflammatory cytokine expression in knee osteoarthritis by rehmannia glutinosa polysaccharides via PI3K/AKT pathway activation at different concentrations. [Journal Article]Knee. 2026 Oct 02; 63:104647. [Online ahead of print]KNEE
- CONCLUSIONS: Rehmannia glutinosa polysaccharide (RGP) exerts a protective effect on cartilage by activating the PI3K/AKT/mTOR signaling pathway to regulate the mitochondrial apoptosis pathway, thereby inhibiting IL-1β-induced apoptosis and inflammatory responses in knee osteoarthritis chondrocytes.
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- Articular congruence, not neutrality: a systematic review of how native knee geometry shapes load-dependent alignment. [Review]Knee. 2026 Oct 01; 63:104649. [Online ahead of print]KNEE
- CONCLUSIONS: The phenomenon is best interpreted as a geometric load-response of the native knee: unequal M/L contact heights produce coronal inclination, and A/P contact-centroid position produces sagittal behavior. The current literature provides multiple convergent manifestations of this mechanism across WB imaging, axial compression, cadaveric stress testing, JLO manipulation, sagittal geometry, meniscal mechanics, and dynamic in-vivo studies. Clinically, this framework is most directly applicable to native knees with preserved meniscal containment and intact or mildly degenerative compartmental congruence, where static alignment phenotypes should be interpreted together with the load paths that produce them. Future work should directly co-measure ΔJLO, Δh, A/P contact position, and early-flexion tilt in the same standardized protocol.
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- Outcomes of supramalleolar tibial derotational osteotomy in paediatric patients with recurrent patellar dislocation or anterior knee pain and associated torsional malalignment. [Journal Article]Knee. 2026 Sep 30; 63:104644. [Online ahead of print]KNEE
- CONCLUSIONS: Distal tibial derotation osteotomy for patellofemoral instability or pain in children appears to be safe and may be considered as part of the treatment strategy for patients with torsional malalignment, with the potential to reduce recurrence rates associated with isolated MPFL reconstruction.
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- Feasibility of repeat tibial tubercle osteotomy in re-revision knee arthroplasty. [Journal Article]Knee. 2026 Sep 25; 63:104643. [Online ahead of print]KNEE
- CONCLUSIONS: We conclude that sequential repeat TTO in re-revision surgeries is associated with high union rate and a low complication rate. Our technique for the osteotomy is described in detail.
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- Clinical outcomes of femoral bone tunnel fixation and onlay fixation techniques for medial patellofemoral ligament reconstruction: a systematic review. [Review]Knee. 2026 Sep 25; 63:104613. [Online ahead of print]KNEE
- Medial patellofemoral ligament reconstruction (MPFLR) for treatment of recurrent patellofemoral instability yields excellent outcomes and has been shown to be safe. Femoral fixation can be performed using various methods, however the role of onlay techniques when compared to bone tunnels for femoral fixation during MPFLR has not been fully described in adults.
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- A comparative study of machine learning based automatic diagnosis approaches to diagnose knee osteoarthritis from radiographs. [Review]Knee. 2026 Sep 18; 63:104634. [Online ahead of print]KNEE
- CONCLUSIONS: The review discusses challenges like data imbalance, model generalization, and clinical interpretability, along with future research directions. Overall, this review aims to help researchers and clinicians understand the current state of KOA diagnosis and develop robust, scalable, and clinically applicable systems.
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- Optimizing perioperative intravenous corticosteroid dosing for postoperative outcomes in total joint arthroplasty: a network meta-analysis. [Journal Article]Knee. 2026 Sep 18; 63:104636. [Online ahead of print]KNEE
- CONCLUSIONS: Low-dose dexamethasone generally provides adequate benefits, while higher doses may provide additional analgesia in TKA or patients at risk of severe postoperative pain.
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- No difference in short-term revision risk between robot-assisted total knee arthroplasty and conventional techniques: An analysis of 79,115 total knee arthroplasties in the Dutch arthroplasty register. [Journal Article]Knee. 2026 Sep 17; 63:104632. [Online ahead of print]KNEE
- CONCLUSIONS: In this nationwide analysis, RA-TKA and cTKA demonstrated comparable short-term revision outcomes, with overall revision rates remaining low in both groups. Nonetheless, mean follow-up time was short, so additional research is required to evaluate mid- to long-term results and to indicate potential superiority of one technique over another.
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- Injectable hydrogel filled into porous scaffolds combined with ultrasound-controlled drug release. [Journal Article]Knee. 2026 Sep 17; 63:104633. [Online ahead of print]KNEE
- CONCLUSIONS: The combination of injectable hydrogels with 3D-printed scaffolds demonstrates an effective strategy for bone defect repair, and integration with ultrasound enables long-term controlled and on-demand drug delivery.
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- Efficacy and safety of intra-articular disease-modifying osteoarthritis drugs (DMOADs) for knee osteoarthritis: a Bayesian network meta-analysis of randomised controlled trials. [Journal Article]Knee. 2026 Sep 17; 63:104642. [Online ahead of print]KNEE
- CONCLUSIONS: Current low-level evidence indicates that no intra-articular DMOADs provide significant structural or symptomatic benefit. This highlights the need for efficacious agents and optimised trial designs with standardised imaging protocols, clinically relevant endpoints, adequate statistical power, and long-term follow-up to accurately assess disease-modifying effects. Future studies should also evaluate novel DMOADs with improved efficacy and safety.
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- How to conduct an effective clinical trial of cell based injection therapy for articular cartilage lesions of the knee. [Journal Article]Knee. 2026 Sep 15; 63:104640. [Online ahead of print]KNEE
- Conducting an effective clinical trial for mesenchymal stem cell therapy in the treatment of osteochondral defects of the knee in the post-traumatic and/or osteoarthritic knee requires consideration of a multitude of factors not only limited to study design, but also mesenchymal stem cell (MSC) formulation and delivery concerns. Considerations include lidocaine as use as a placebo control as well…
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- Association of testosterone replacement therapy on medical and implant-related complications after total knee arthroplasty: a systematic review and meta-analysis. [Review]Knee. 2026 Sep 15; 63:104637. [Online ahead of print]KNEE
- CONCLUSIONS: TRT was not associated with early thromboembolic complications after TKA but was associated with higher risks of AKI and implant-related complications. These findings suggest TRT may represent an associated perioperative risk factor in patients undergoing TKA.
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- Design and accuracy evaluation of a new surgical instrument for determining cartilage thickness on unworn posterior femoral articular surfaces intraoperatively in kinematically aligned total knee arthroplasty. [Case Reports]Knee. 2026 Sep 15; 63:104641. [Online ahead of print]KNEE
- CONCLUSIONS: The new surgical instrument provides surgeons with a proven method for intra-operative measurement of cartilage thickness in the unworn posterior femoral condyle.
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