(The Prostate[TA])
6,254 results
  • Real-World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON-3 Study. [Journal Article]
    Prostate. 2026 Oct 12. [Online ahead of print]Incorvaia L, Mollica V, … Santoni MP
  • CONCLUSIONS: This multinational real-world analysis demonstrates substantial heterogeneity in HRR testing uptake and testing pathways across participating ARON-3 centres. Testing was more commonly performed in patients with more advanced disease features, suggesting that clinically relevant subgroups may still be differentially selected for genomic assessment. Broader and more standardised implementation of comprehensive HRR profiling may improve the identification of actionable alterations and strengthen precision medicine in prostate cancer.
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  • Stage-Specific Racial Disparities in Prostate Cancer Survival Outcomes. [Journal Article]
    Prostate. 2026 Oct 06. [Online ahead of print]Minas TZ, Butler EN, … Yates CP
  • CONCLUSIONS: Disparate survival outcomes for AA men with PCa emerge mainly at Stage 3 or 4 diagnosis, emphasizing the importance of early detection for these men. Notably, AA patients with advanced-stage disease were more likely to receive hormone therapy alone, a treatment pattern that may contribute to racial disparities in PCa survival.
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  • Human Prostate Cell Lines: Derivation, Molecular Characteristics and Appropriate Use. [Review]
    Prostate. 2026 Oct 06. [Online ahead of print]Abohamra H, Pearce KMP
  • CONCLUSIONS: Several descriptions repeated in the secondary literature are not supported by the primary characterization of the lines concerned. Selection of a line from the research question rather than from availability, verification of the relevant target in the working stock, authentication by short tandem repeat profiling, and full reporting of passage number and culture conditions would remove a substantial part of the variability presently seen in this literature.
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  • Urinary Soluble Collagen Levels Are Associated With Moderate/Severe LUTS. [Journal Article]
    Prostate. 2026 Oct 06. [Online ahead of print]Sarna-McCarthy M, Quetant C, … Macoska JAP
  • CONCLUSIONS: Urinary soluble collagen levels increase concurrently with moderate/severe LUTS, and are stable in urine after long-term storage at -80°C. These findings suggest that urinary soluble collagen levels may serve as suitable diagnostic biomarkers for prostatic collagenization consistent with fibrosis in association with LUTS. Potentially, urinary soluble collagen levels may be used as surrogate endpoint biomarkers to assess the efficacy of anti-fibrotic medical or surgical therapies to decrease prostatic urethral obstruction or resistance, and alleviate LUTS.
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  • Is a Few Too Many? Alcohol Consumption and Prostate Cancer Upgrading During Active Surveillance. [Journal Article]
    Prostate. 2026 Sep 27. [Online ahead of print]Campbell J, Higgins MI, … Trock BJP
  • CONCLUSIONS: In a large prospective cohort of men undergoing AS, higher baseline self-reported alcohol consumption was associated with upgrading to ≥ GG2 on surveillance biopsy. No association was observed with extreme upgrading. These findings may inform clinical counseling regarding alcohol use during AS, although further studies are needed to validate our findings.
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