(Thyroid[TA])
6,373 results
  • Radiofrequency Ablation of Calcified Papillary Thyroid Microcarcinoma: Long-Term Imaging Evolution and Clinical Outcomes. [Journal Article]
    Thyroid. 2026 Oct 09; :10507256261494905. [Online ahead of print]Jeong SY, Baek SM, … Baek JHT
  • CONCLUSIONS: In this retrospective cohort, RFA achieved complete resolution of the viable soft-tissue component with a low complication rate in low-risk PTMC, both with and without intratumoral calcification. Technical success was achieved in 100% of tumors regardless of calcification status, and no significant difference in outcomes was observed between the calcified and noncalcified groups. These findings suggest that intratumoral calcification does not preclude effective ablation.
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  • Smartphone-Based Deep Learning Exophthalmometry in Thyroid Eye Disease: A Multicenter, Multiethnic Validation Study. [Journal Article]
    Thyroid. 2026 Oct 07; :10507256261495636. [Online ahead of print]Moon JH, Park J, … Ko JT
  • CONCLUSIONS: An artificial intelligence model fine-tuned for nonstudio facial photographs achieved Hertel-level agreement and reliable severity discrimination across 2 ethnicities and 12 smartphones, both for patient self-acquired smartphone selfies and for clinician-acquired routine clinic photographs, providing a scalable approach for patient-facing and clinic-based monitoring of TED severity, pending further longitudinal validation.
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  • Longitudinal Ultrasonographic Analysis of Involutional Changes after Radiofrequency Ablation of Papillary Thyroid Microcarcinoma. [Journal Article]
    Thyroid. 2026 Oct 07; :10507256261494909. [Online ahead of print]Ham T, Lee JY, … Kim JHT
  • CONCLUSIONS: RFA of low-risk PTMC achieves an excellent final complete disappearance rate while frequently inducing characteristic US features, including capsular retraction, postablational strands, and postablational parenchymal hypoechogenicity. Recognition of these US involutional changes is crucial for accurate posttreatment monitoring and for avoiding misinterpretation of benign healing changes as pathological findings, and may inform imaging-based post-RFA surveillance.
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  • RET Variant Reclassification across Demographic Sub-Groups in a Large-Scale Clinical Population. [Journal Article]
    Thyroid. 2026 Oct 07; :10507256261493762. [Online ahead of print]Fergus KB, Richardson ME, … Grubbs EGT
  • CONCLUSIONS: The expansion of RET germline testing coincided with substantial reclassification of VUSs, highlighting the importance of periodic laboratory reassessment. Most reclassifications were benign, which is cautiously reassuring for clinical counseling of patients. Both further characterization of RET variants and society guidance on clinical management of VUS test results are needed as genetic testing continues to expand.
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  • Genetic Heterogeneity in Susceptibility to Familial Thyroid Nodular Disease. [Journal Article]
    Thyroid. 2026 Sep 11; :10507256261485457. [Online ahead of print]Chong AS, Paschke R, … Rivera BT
  • CONCLUSIONS: This study highlights the substantial genetic heterogeneity underlying familial TFND. While most kindreds lacked clear monogenic causes, DICER1 explained familial disease in one pedigree, whereas the SLC26A4 findings supported a likely somatic second-hit mechanism in a single affected member of another pedigree without accounting for the familial aggregation. The findings support a multifactorial etiology and suggest that TFND represents a phenotypic manifestation within broader hereditary syndromes. Integrating family-based sequencing with functional validation will be critical to fully delineate pathogenic mechanisms and broaden the spectrum of genes implicated in thyroid nodular disease.
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  • Afirma Xpression Atlas Alteration Status Is Associated with Malignancy Risk in Indeterminate Thyroid Nodules. [Journal Article]
    Thyroid. 2026 Aug 28; :10507256261484715. [Online ahead of print]Peng TD, Hughes EG, … Livhits MJT
  • CONCLUSIONS: Alteration detection by Afirma XA offers incremental malignancy risk stratification beyond GSC-suspicious classification alone in indeterminate thyroid nodules. The substantial malignancy rate in GSC-suspicious alteration-negative nodules, with histopathologic features similar to those of alteration-positive nodules, supports continued consideration of surgical resection in such cases.
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