| Title | [The improvement of echocardiographic assessment of the left ventricle by the use of perflenapent and harmonic imaging] | | Author(s) | Olszewski R, Marciniak W, Nowicki A, Gil M, Etienne J, Karłowicz P, Adamus J | | Institution | Kliniki Kardiologii Centralnego Szpitala Klinicznego WAM w Warszawie. | | Source | Pol Merkur Lekarski 1998 Sep; 5(27):132-4. | | MeSH | Adult
Aged
Contrast Media
Echocardiography
Female
Fluorocarbons
Heart Function Tests
Heart Ventricles
Humans
Male
Middle Aged
Pilot Projects
| | Abstract | Contrast echocardiography and harmonic imaging (HI) are promising new modalities applied in order to obtain improved visualisation of the left ventricle. Perflenapent (EchoGen, Abbott) is a new generation echocardiographic contrast agent that crosses the pulmonary capillary bed and produces long-term ventricle opacification. Our aim was to assess the left ventricle endocardial visualisation after perflenapent infusion and HI technique. We studied a pilot group of 10 patients (mean age 52.5 +/- 7.6, mean weight 76.9 +/- 10.1 kg, one female) with previously obtained sub-optimal non-contrast echocardiograms. Perflenapent was injected intravenously at dosis 0.05 ml/kg. Echocardiography was performed before perflenapent injection and during the time between injection and LV image disappearance. Images were assessed using four-point scale, 0 standing for the poorest and 3 for excellent visualisation. Perflenapent produced full chamber opacification in all pts. Contrast effect was observed for 550-15824 sec and myocardial enhancement was seen for 176-2116 sec after i.v. administration. After perflenapent administration, endocardial border was significantly better visible than before (1.9 +/- 0.57 vs. 2.9 +/- 0.31, p < 0.001). No hemodynamic effects were noted, as assessed by oxygen saturation, blood pleasure and heart rate. A mild, transient somnolence was seen in one pt. Perflenapent improved left ventricular function diagnostic capabilities, and provided enhanced visualisation of the myocardium. | | Language | pol | | Pub Type(s) | Comparative Study
English Abstract
Journal Article
| | PubMed ID | 10101477 |
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