A qualitative estimate of the influence of halcinonide concentration and urea on the reservoir formation in the stratum corneum. Skin pharmacology and applied skin physiology. [Skin Pharmacol Appl Skin Physiol] Journal article

Title	A qualitative estimate of the influence of halcinonide concentration and urea on the reservoir formation in the stratum corneum.
Author(s)	Clarys P, Gabard B, Barel AO
Institution	General and Biological Chemistry, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Belgium. pclarys@vub.ac.be
Source	Skin Pharmacol Appl Skin Physiol 1999 Jan-Apr; 12(1-2):85-9.
MeSH	Administration, Topical Adolescent Adult Anti-Inflammatory Agents Colorimetry Dose-Response Relationship, Drug Drug Interactions Epidermis Female Glucocorticoids Halcinonide Humans Male Time Factors Urea
Abstract	The existence of a stratum corneum reservoir for topically applied substances is well known. Data concerning the stratum corneum retention time are important for the elaboration of optimal topical treatment. We used the re-occlusion technique followed by skin colour measurements (Chromametry) for the evaluation of the stratum corneum retention time of halcinonide. We found a significant reservoir for halcinonide up to 5 days after the initial application. The retention was found to be corticosteroid concentration and formulation dependent.
Language	eng
Pub Type(s)	Journal Article
PubMed ID	10325587

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