Yuste JR, Beloqui O, De la Peña A, Prieto J
[Antiphospholipid syndrome] [Journal Article, Review]
Rev Med Univ Navarra 1998 Oct-Dec; 42(4):194-207.
Antiphospholipid syndrome is a well-defined clinical and serological entity characterized by arterial and/or venous thrombosis, recurrent abortion and thrombocytopenia. Anticardiolipin antibodies and lupus anticoagulant are autoantibodies directed against negatively charged phospholipids, which represent the serologic criteria for the diagnosis of the antiphospholipid syndrome. In this review the pathogenic mechanisms of anticardiolipin antibodies, their clinical findings and the current therapeutical strategies are discussed.
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