| Title | Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models. | | Author(s) | Sengoku T, Morita K, Sakuma S, Motoyama Y, Goto T | | Institution | Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical, Osaka, Japan. | | Source | Eur J Pharmacol 1999 Aug 27; 379(2-3):183-9. | | MeSH | Animals
Dermatitis, Atopic
Drug Evaluation, Preclinical
Female
Immunosuppressive Agents
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Rats
Rats, Inbred BN
Rats, Inbred Lew
Tacrolimus
Tuberculin
Vasculitis, Allergic Cutaneous
| | Abstract | The effects of FK506 (tacrolimus hydrate) ointment on cutaneous allergic reactions in mice and rats were investigated. FK506 ointment showed significant suppressive effects on delayed allergic reactions in both species, and especially in rats, its inhibitory action was much stronger than that of alclometasone dipropionate, a so-called medium class steroid ointment. On the other hand, FK506 ointment did not inhibit the immediate allergic reaction in rats. FK506 ointment suppressed the delayed allergic reactions in locally passively sensitized mice to the same degree as that in actively sensitized mice. Accordingly, it is speculated that FK506 ointment inhibits the activation of sensitized T lymphocytes (Th1 cells) already accumulated in the dermis. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 10497905 |
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