| Title | Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats. | | Author(s) | Ghasi S, Nwobodo E, Ofili JO | | Institution | Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu. | | Source | J Ethnopharmacol 2000 Jan; 69(1):21-5. | | MeSH | Animals
Anticholesteremic Agents
Blood Proteins
Cholesterol
Dietary Fats
Hypercholesterolemia
Kidney
Liver
Male
Medicine, Ayurvedic
Plant Extracts
Plant Leaves
Rats
Rats, Wistar
Serum Albumin
| | Abstract | The leaves of Moringa oleifera Lam (Moringaceae) are used by the Indians in their herbal medicine as a hypocholesterolemic agent in obese patients. The scientific basis for their use in hypercholesterolemia was therefore examined. It was found that administration of the crude leaf extract of Moringa oleifera along with high-fat diet decreased the high-fat diet-induced increases in serum, liver, and kidney cholesterol levels by 14.35% (115-103.2 mg/100 ml of serum), 6.40% (9.4-8.8 mg/g wet weight) and 11.09% (1.09-0.97 mg/g wet weight) respectively. The effect on the serum cholesterol was statistically significant. No significant effect on serum total protein was observed. However, the crude extract increased serum albumin by 15.22% (46-53 g/l). This value was also found to be statistically significant. It was concluded that the leaves of Moringa oleifera have definite hypocholesterolemic activity and that there is valid pharmacological basis for employing them for this purpose in India. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 10661880 |
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