| Title | Comparative palatability of 22 liquid antacids. | | Author(s) | Temple ME, Nahata MC | | Institution | College of Pharmacy, The Ohio State University, Columbus, USA. temple.9@osu.edu | | Source | Aliment Pharmacol Ther 2000 Apr; 14(4):421-5. | | MeSH | Adolescent
Adult
Antacids
Comparative Study
Female
Humans
Male
Middle Aged
Single-Blind Method
Taste
| | Abstract | OBJECTIVE: To compare the palatability, acid neutralizing capability, and costs of different antacids.
METHODS: Volunteers between the ages of 18 and 60 years were given 22 antacids. All antacids were given during a 4-h period in two groups of 11 antacids each. Subjects sampled each antacid in a manner similar to wine tasting and rated each antacid on its smell, taste, texture and aftertaste using a scale of 1-9; 1 being the worst and 9 the best.
RESULTS: A total of 73 adults completed the study. Mylanta Lemon Twist and Mylanta Cherry Crème were the most palatable antacids; however, overall the palatability of all the antacids was poor. Maalox MS Cool Mint and ES Gaviscon were the least palatable. The extra strength antacids had the most acid neutralizing capability, and thus would require smaller doses. Amphogel was the most costly antacid per mEq of acid neutralized. Age and gender did not affect the palatability scores.
CONCLUSION: Although the regular strengths of Mylanta Lemon Twist and Mylanta Cherry Crème were the most palatable, the extra strength versions of these products have twice the acid neutralizing capability and thus, half the volume is required for each dose. Therefore, these agents may be the antacids of choice. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
| | PubMed ID | 10759621 |
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