| Title | Spectroscopic and dynamic studies of the epidermal chromophores trans-urocanic acid and eumelanin. | | Author(s) | Simon JD | | Institution | Department of Chemistry, Duke University, and Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27708, USA. | | Source | Acc Chem Res 2000 May; 33(5):307-13. | | MeSH | Free Radicals
Humans
Melanins
Oxygen Consumption
Particle Size
Photochemistry
Photoreceptors
Skin
Skin Aging
Skin Neoplasms
Spectrophotometry
Stereoisomerism
Ultraviolet Rays
Urocanic Acid
| | Abstract | Photoaging and skin cancer can result from the exposure of skin to ultraviolet A (UV-A, 320-400 nm) radiation. The detailed chemical mechanisms by which these processes occur are not known, but they must begin with the absorption of a UV-A photon by one or more photoreceptor(s) within the skin. The situation is complicated by the lack of understanding of the photoreactions of many of the UV-A-absorbing molecules in skin. In this Account, we describe recent research efforts directed at elucidating the UV-A-induced photoreactivity of two light-absorbing epidermal photoreceptors: trans-urocanic acid and eumelanin. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 10813875 |
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