| Title | Single-dose vicoprofen compared with acetaminophen with codeine and placebo in patients with acute postoperative pain after third molar extractions. | | Author(s) | Ziccardi VB, Desjardins PJ, Daly-DeJoy E, Seng GF | | Institution | University of Medicine and Dentistry of New Jersey, Department of Oral and Maxillofacial Surgery, Newark 07103-2400, USA. ziccarvb@umdnj.ed | | Source | J Oral Maxillofac Surg 2000 Jun; 58(6):622-8. | | MeSH | Acetaminophen
Adolescent
Adult
Analgesics
Analysis of Variance
Chi-Square Distribution
Codeine
Comparative Study
Double-Blind Method
Drug Combinations
Drug Evaluation
Facial Pain
Female
Humans
Hydrocodone
Ibuprofen
Male
Molar, Third
Pain Measurement
Pain, Postoperative
Research Support, Non-U.S. Gov't
Statistics, Nonparametric
Tooth Extraction
Tooth, Impacted
| | Abstract | PURPOSE: The purpose of this double-blind, randomized study was to compare the efficacy and safety of a single dose of the following medications: 2 tablets of Vicoprofen (ibuprofen 200 mg/hydrocodone 7.5 mg; Knoll Pharmaceutical Co, Mount Olive, NJ), 2 tablets ofp6 acetaminophen with codeine phosphate (acetaminophen 300 mg/codeine 30 mg), and 2 tablets of placebo in the management of moderate to severe postoperative dental pain after surgical extraction of at least one impacted mandibular third molar.
PATIENTS AND METHODS: One hundred twenty-five patients (75 women, 50 men) participated in the study. The time of first perceptible pain relief and meaningful pain relief were measured using a stopwatch technique. Pain intensity and pain relief scores were recorded using standard verbal descriptors at 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, and 8 hours after dosing. At the conclusion of the study, patients completed a global evaluation for the effectiveness of the study medication.
RESULTS: Both active treatments were superior to placebo for all analgesic measures. Pain relief scores were significantly better for Vicoprofen than placebo throughout the study and significantly better than for acetaminophen with codeine from 2 through 8 hours after dosing. The duration of analgesia (time to remedication) was significantly longer for Vicoprofen (median, 5.50 hours) compared with acetaminophen with codeine (median, 3.03 hours) and placebo (median, 1.00 hours). Mean global evaluation for Vicoprofen was significantly better than for placebo and acetaminophen with codeine. Overall, there were no significant differences in the adverse event profile among the 3 treatment groups.
CONCLUSIONS: Vicoprofen was found to be an effective postoperative analgesic medication in the management of acute postoperative dental pain. Its total analgesic effect, duration of analgesia, and global evaluation were superior to acetaminophen with codeine and placebo in this study model. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
| | PubMed ID | 10847283 |
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