Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media. The Journal of infectious diseases. [J Infect Dis] Journal article | | Title | Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media. | | Author(s) | Rapola S, Jäntti V, Haikala R, Syrjänen R, Carlone GM, Sampson JS, Briles DE, Paton JC, Takala AK, Kilpi TM, Käyhty H | | Institution | National Public Health Institute, Dept. of Vaccines, 00300 Helsinki, Finland. satu.rapola@ktl.fi | | Source | J Infect Dis 2000 Oct; 182(4):1146-52. | | MeSH | Antibodies, Bacterial
Antigens, Bacterial
Bacterial Proteins
Carrier Proteins
Carrier State
Cohort Studies
Finland
Humans
Infant
Lipoproteins
Longitudinal Studies
Membrane Transport Proteins
Otitis Media
Pneumococcal Infections
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Streptococcus pneumoniae
Streptolysins
| | Abstract | Pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA), and pneumolysin (Ply) are common to virtually all Streptococcus pneumoniae isolates. They are immunogenic and protective against pneumococcal challenge in animals and are the major candidates for a protein-based pneumococcal vaccine for humans. However, little is known of the natural development of antibodies to these proteins in humans. The objective of this study was to evaluate the natural development of antibodies to PspA, PsaA, and Ply in relation to pneumococcal infection and carriage in young children. Serum antibodies to these proteins were measured by EIA in children at ages 6, 12, 18, and 24 months and in their mothers. All age groups were capable of producing antibodies to the 3 proteins. The antibody concentrations increased with age and were strongly associated with pneumococcal exposure, whether by carriage or infection (acute otitis media). | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 10979911 |
|
|
| |
Advertise on this site.
| | |
|
