IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease. The Journal of infectious diseases. [J Infect Dis] Journal article

Title	IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease.
Author(s)	Rowley AH, Shulman ST, Mask CA, Finn LS, Terai M, Baker SC, Galliani CA, Takahashi K, Naoe S, Kalelkar MB, Crawford SE
Institution	Ward 12-140, Pediatrics W-140, Northwestern University Medical School, Chicago, IL 60611-3008, USA. a-rowley@northwestern.edu
Source	J Infect Dis 2000 Oct; 182(4):1183-91.
MeSH	Acute Disease Cause of Death Child Child, Preschool Coronary Vessels Ethnic Groups Female Humans Immunoglobulin A Infant Japan Kidney Male Mucocutaneous Lymph Node Syndrome Pancreas Plasma Cells Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Respiratory System United States
Abstract	The etiology and pathogenesis of Kawasaki disease (KD) remain unknown. As previously reported, in US patients with acute KD, IgA plasma cells (PCs) infiltrate the vascular wall. To determine whether IgA PCs are increased at mucosal sites in KD and to determine whether other nonvascular KD tissues are infiltrated by IgA PCs, the cells were immunolocalized and quantitated in tissue sections taken from 18 US and Japanese patients who died of acute KD and from 10 age-matched controls. IgA PCs were significantly increased in the trachea of patients who died of acute KD, compared with controls (P<.01), a finding that was similar to findings in children with fatal respiratory viral infection. IgA PCs also infiltrated coronary artery, pancreas, and kidney in all KD patients. These findings strongly support entry of the KD etiologic agent through the upper respiratory tract, resulting in an IgA immune response, with systemic spread to vascular tissue, pancreas, and kidney.
Language	eng
Pub Type(s)	Journal Article
PubMed ID	10979916

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