Enhanced left ventricular endocardial border delineation with an intravenous injection of SonoVue, a new echocardiographic contrast agent: A European multicenter study. Echocardiography (Mount Kisco, N.Y.) [Echocardiography] Journal article | | Title | Enhanced left ventricular endocardial border delineation with an intravenous injection of SonoVue, a new echocardiographic contrast agent: A European multicenter study. | | Author(s) | Senior R, Andersson O, Caidahl K, Carlens P, Herregods MC, Jenni R, Kenny A, Melcher A, Svedenhag J, Vanoverschelde JL, Wandt B, Widgren BR, Williams G, Guerret P, la Rosee K, Agati L, Bezante G | | Institution | Northwick Park Hospital and Institute of Medical Research, Department of Cardiovascular Medicine, Harrow, Middlesex, United Kingdom. roxysenior@virgin.net | | Source | Echocardiography 2000 Nov; 17(8):705-11. | | MeSH | Aged
Comparative Study
Confidence Intervals
Contrast Media
Coronary Disease
Cross-Over Studies
Dose-Response Relationship, Drug
Echocardiography
Female
Great Britain
Humans
Injections, Intravenous
Male
Middle Aged
Phospholipids
Prospective Studies
Radiographic Image Enhancement
Reference Values
Sensitivity and Specificity
Sulfur Hexafluoride
| | Abstract | The safety and efficacy of SonoVue (also referred to as BR1), a new contrast agent for delineating endocardial border of the left ventricle after intravenous administration, was assessed. Two hundred and eighteen patients with suspected coronary artery disease undergoing fundamental echocardiography for the assessment of left ventricle were enrolled in a prospective multicenter, single blind, cross-over study with random sequence allocation of four different doses of SonoVue. Endocardial border definition in the apical and parasternal views was scored as 0 = not visible, 1 = barely visible, and 2 = well visualized before and after contrast enhancement. Analysis was performed by two pairs of off-site observers. Safety of SonoVue was also assessed. Results of our study indicated that the mean improvements in the endocardial border visualization score were as follows: 3.1 +/- 7.8 (95% CI, 2.5 and 3.7) for 0.5 ml, 3.4 +/- 8.0 (95% CI, 2.8 and 4.0) for 1 ml, 3.4 +/- 7.9 (95% CI, 2.8 and 4.0) for 2 ml, and 3.7 +/- 8.0 (95% CI, 3.1 and 4.3) for 4 ml (P < 0.05 for all doses from baseline). Changes from baseline in endocardial visualization scores were also seen in the apical views (P < 0.05) and they were dose-dependent (P < 0.001). Similar enhancements of endocardial visualization scores were observed in the apical views in patients with suboptimal baseline echocardiographic images. Diagnostic confidence for assigning a score and image quality also were significantly better following contrast enhancement. No significant changes in the laboratory parameters and vital signs were noted following contrast enhancement, and the side effects were minimal. It was concluded that SonoVue is safe and effective in delineating endocardial border, including in patients with suboptimal baseline images. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
| | PubMed ID | 11153016 |
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