| Title | Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis. | | Author(s) | Sanguinetti M, Ardito F, Fiscarelli E, La Sorda M, D'Argenio P, Ricciotti G, Fadda G | | Institution | Istituto di Microbiologia, Università Cattolica del S. Cuore, Ospedale Pediatrico Bambino Gesù, Rome, Italy. msanguinetti@rm.unicatt.it | | Source | J Clin Microbiol 2001 Feb; 39(2):816-9. | | MeSH | Adult
Anti-Bacterial Agents
Cystic Fibrosis
Drug Resistance, Multiple
Drug Therapy, Combination
Fatal Outcome
Humans
Lung Diseases
Lung Transplantation
Male
Microbial Sensitivity Tests
Mycobacterium
Mycobacterium Infections
Postoperative Complications
Research Support, Non-U.S. Gov't
| | Abstract | We report a case of fatal pulmonary infection caused by Mycobacterium abscessus in a young patient with cystic fibrosis, who underwent bipulmonary transplantation after a 1-year history of severe lung disease. Fifteen days after surgery he developed septic fever with progressive deterioration in lung function. M. abscessus, initially isolated from a pleural fluid specimen, was then recovered from repeated blood samples, suggesting a disseminated nature of the mycobacterial disease. Drug susceptibility testing assay, performed on two sequential isolates of the microorganism, showed a pattern of multidrug resistance. Despite aggressive therapy with several antimycobacterial drugs, including clarithromycin, the infection persisted, and the patient died. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 11158161 |
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