| Title | Delayed closure of epiphyseal cartilages induced by the aromatase inhibitor anastrozole. Would it help short children grow up? |
| Author(s) | Faglia G, Arosio M, Porretti S |
| Institution | Institute of Endocrine Sciences, Ospedale Maggiore IRCCS, University of Milan, Italy. giovanni.faglia@excite.com |
| Source | J Endocrinol Invest 2000 Dec; 23(11):721-3. |
| MeSH | Aromatase Inhibitors
Body Height
Bone Development
Child, Preschool
Enzyme Inhibitors
Growth Disorders
Growth Plate
Human Growth Hormone
Humans
Male
Nitriles
Puberty, Precocious
Triazoles
|
| Abstract | Estrogens locally generated from androgen precursors due to the action of aromatase play a main role in epiphyseal cartilage fusion. Treatment with an aromatase inhibitor (anastrozole, 1 mg/day for 3 yr) in a boy previously operated on for a hamartoma causing precocious puberty and presenting with advanced bone maturation and nearly fused epiphyseal cartilages, slowed cartilage fusion consenting a higher final stature than expected (164.4 cm vs 158.4 cm). It is suggested that treatment with aromatase inhibitors, alone or in combination with rh-GH, may also be useful in children with constitutional short stature in order to delay epiphyseal closure and improve the final height. |
| Language | eng |
| Pub Type(s) | Case Reports
Journal Article
|
| PubMed ID | 11194703 |
