Interactions of lymphotoxin alpha (TNF-beta), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis. Journal of periodontology. [J Periodontol] Journal article | | Title | Interactions of lymphotoxin alpha (TNF-beta), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis. | | Author(s) | Hollá LI, Fassmann A, Vasků A, Znojil V, Vanek J, Vácha J | | Institution | Institute of Pathological Physiology, Medical Faculty, Masaryk University Brno, Czech Republic. holla@med.muni.cz | | Source | J Periodontol 2001 Jan; 72(1):85-9. | | MeSH | Adult
Alleles
Case-Control Studies
Chi-Square Distribution
Chromosome Mapping
DNA Transposable Elements
Endothelin-1
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Homozygote
Humans
Lymphotoxin
Male
Middle Aged
Odds Ratio
Peptidyl-Dipeptidase A
Periodontitis
Polymorphism, Genetic
Research Support, Non-U.S. Gov't
Risk Factors
Sequence Deletion
Statistics
| | Abstract | BACKGROUND: Adult periodontitis is a complex multifactorial disease whose etiology is not well defined. To investigate whether the genes encoded within the HLA class III region may confer susceptibility to periodontitis, polymorphisms in the ET-1 and TNF-beta genes were analyzed together with the I/D polymorphism of the ACE gene.
METHODS: We determined allele and genotype frequencies of the NcoI bi-allelic polymorphism of the TNF-beta gene, the I/D (insertion/deletion) polymorphism of the ACE gene, and the TaqI polymorphism of the ET-1 gene in 63 Caucasian patients with adult periodontitis and 95 orally healthy controls.
RESULTS: We found a significant difference in a 3 locus combination of genotypes between patients and controls (P<0.05). In the next analyses, no significant differences were found in allele frequencies of single genes, but we did find a significant difference in the genotype distribution between cases and controls for TNF-beta (P<0.03). Differences were also observed for 2 locus combinations of ACE and TNF-beta genotypes (P<0.03), and the ET-1 and TNF-beta (P<0.05) genes. Evidence of deviation from Hardy-Weinberg equilibrium was observed in the periodontitis group for TNF-beta, with an absence of the B1B1 homozygotes in patients.
CONCLUSIONS: This study is of an exploratory nature. Considering the number of significant results, however, at least a part of the observed associations may obviously be real and our findings suggest that interactions of the TNF-beta, ET-1, and ACE genes may be involved in susceptibility to adult periodontitis. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 11210078 |
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