[Capozide-50 alone and in combination with melatonin in therapy of hypertension] Klinicheskaia meditsina. [Klin Med (Mosk)] Journal article

Title	[Capozide-50 alone and in combination with melatonin in therapy of hypertension]
Author(s)	Zaslavskaia RM, Biiasilov NS, Akhmetov KZh, Teĭblium MM
Source	Klin Med (Mosk) 2000; 78(11):39-41.
MeSH	Antioxidants Blood Pressure Captopril Circadian Rhythm Comparative Study Drug Administration Schedule Drug Combinations Drug Therapy, Combination English Abstract Female Heart Rate Humans Hydrochlorothiazide Hypertension Male Melatonin Middle Aged Prognosis
Abstract	Monotherapy with caposide-50 (C-50) was compared to combined therapy C-50 + melatonin in 22 patients with essential hypertension stage II (mean age 60 years). The patients were divided into two groups. Group 1 received C-50 at 8.00 a.m., group 2 received C-50 at 8.00 a.m. and melatonin at 10.00 p.m. in a dose 3 mg. Before the treatment and 14 days after it echo-CG was made to assess hemodynamics. Also, 24-h monitoring of arterial pressure was performed. The findings were analysed with variance statistics and cosinor-analysis. Group 1 achieved a moderate hypotensive effect. Circadian rhythm of systolic blood pressure was abnormal. Group 2 patients achieved more pronounced decline of systolic, diastolic and mean arterial pressures. Circadian rhythm of these pressure did not return to normal.
Language	rus
Pub Type(s)	Clinical Trial Journal Article Randomized Controlled Trial
PubMed ID	11232529

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