Which antiphospholipid antibodies should be measured in the antiphospholipid syndrome? Haemostasis [Haemostasis] Journal article

Title	Which antiphospholipid antibodies should be measured in the antiphospholipid syndrome?
Author(s)	Galli M
Institution	Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy. ematologia@cyberg.it
Source	Haemostasis 2000.:57-62.
MeSH	Antibodies, Anticardiolipin Antiphospholipid Syndrome Autoantibodies Autoantigens Autoimmune Diseases Case-Control Studies Cross-Sectional Studies Glycoproteins Humans Lupus Coagulation Inhibitor Odds Ratio Prospective Studies Prothrombin Retrospective Studies Risk Factors Sensitivity and Specificity Thrombophilia beta 2-Glycoprotein I
Abstract	The results of an analysis of studies published over a 10-year period that addressed the association between antiphospholipid antibodies (aPLs) and thromboembolic events in patients with the antiphospholipid syndrome (APS) are reported. It would appear that lupus anticoagulants are the strongest risk factor for thromboembolic events in aPL-positive patients. Consequently, it is suggested that all patients with clinical manifestations of APS should be tested for these antibodies. On the other hand, the results do not unequivocally show that measurement of anticardiolipin antibodies is of help in defining the thrombotic risk of patients. Furthermore, they only partially support the notion that anti-beta 2-glycoprotein I and antiprothrombin antibodies may be independent risk factors for thrombosis.
Language	eng
Pub Type(s)	Journal Article Review
PubMed ID	11251342

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