| Title | Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts. | | Author(s) | Szeto CY, Tang NL, Lee DT, Stadlin A | | Institution | Department of Anatomy, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. | | Source | Neuroreport 2001 May 8; 12(6):1103-6. | | MeSH | Adult
Asian Continental Ancestry Group
Chi-Square Distribution
Exons
Female
Gene Frequency
Genotype
Heroin Dependence
Humans
Introns
Logistic Models
Male
Polymorphism, Genetic
Receptors, Opioid, mu
| | Abstract | Mu opioid receptor (MOR) has been shown to be associated with alcoholism and opioid dependence. The present study examined the involvement of a polymorphism in A118G in exon 1 and C1031G in intron 2 of the MOR gene in 200 Chinese heroin-dependent and 97 control subjects. Results showed a significant association for both A118G and C1031G polymorphisms and opioid dependence. The G allele is more common in the heroin-dependent group (39.5% and 30.8% for A118G and C1031G polymorphisms, respectively) when compared to the controls (29.4% and 21.1% for A118G and C1031G polymorphisms, respectively). This study suggests that the variant G allele of both A118G and C1031G polymorphisms may contribute to the vulnerability to heroin dependence. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 11338173 |
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