Antibodies to capsular polysaccharides of group B Streptococcus in pregnant Canadian women: relationship to colonization status and infection in the neonate. The Journal of infectious diseases. [J Infect Dis] Journal article | | Title | Antibodies to capsular polysaccharides of group B Streptococcus in pregnant Canadian women: relationship to colonization status and infection in the neonate. | | Author(s) | Davies HD, Adair C, McGeer A, Ma D, Robertson S, Mucenski M, Kowalsky L, Tyrell G, Baker CJ | | Institution | Departments of Microbiology and Infectious Disease, Pediatrics, and Community Health Sciences and Child Health Research Unit, Alberta Children's Hospital, University of Calgary, Calgary,T2T-5C7, Canada. dele.davies@crha-health.ab.ca | | Source | J Infect Dis 2001 Aug 1; 184(3):285-91. | | MeSH | Adult
Alberta
Antibodies, Bacterial
Canada
Cohort Studies
Comparative Study
Disease Transmission, Vertical
Female
Humans
Immunoglobulin G
Infant, Newborn
Parity
Polysaccharides, Bacterial
Population Surveillance
Pregnancy
Pregnancy Complications, Infectious
Rectum
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Serotyping
Streptococcal Infections
Streptococcus agalactiae
Vagina
| | Abstract | In a cohort study of 1207 pregnant women in Alberta, Canada, the serotype distributions of vaginal-rectal group B Streptococcus (GBS) isolates were compared with all isolates from neonates with invasive GBS disease identified by population-based surveillance. Serum concentrations of Ia, Ib, II, III, and V capsular polysaccharide (CPS)-specific IgG also were determined, according to serotype of the vaginal-rectal colonizing GBS strain. GBS colonization was detected in 19.5% (235 of 1207) of women. Serotype III accounted for 20.6% (48 of 233) of colonizing strains available for typing but for 37% (27 of 73) of invasive isolates from neonates (P<.01). Maternal colonization with type III was least likely to be associated with moderate concentrations of III CPS-specific IgG. Serotype III GBS is more invasive than other serotypes in this population; this may be due, at least in part, to poor maternal type III CPS-specific antibody response. | | Language | eng | | Pub Type(s) | Journal Article
Multicenter Study
| | PubMed ID | 11443553 |
|
|
| |
Advertise on this site.
| | |
|
