| Title | [Preoperative serum levels of the carcinoembryonic antigen (CEA) and prognosis in colorectal cancer] | | Author(s) | Allende T, García Muñiz JL, Vizoso F, Del Casar JM, Raigoso P, Llana B, Serra C, Zeidán N, García-Morán M, Roiz C | | Institution | Servicio de Medicina Nuclear II, Hospital Central de Asturias, Oviedo. tallende@hca.es | | Source | Rev Esp Med Nucl 2001 Aug; 20(5):358-64. | | MeSH | Adenocarcinoma
Adult
Aged
Aged, 80 and over
Carcinoembryonic Antigen
Colorectal Neoplasms
Comparative Study
Disease-Free Survival
English Abstract
Female
Follow-Up Studies
Humans
Life Tables
Male
Middle Aged
Multivariate Analysis
Neoplasm Proteins
Neoplasm Staging
Preoperative Care
Prognosis
Prospective Studies
Spain
Survival Analysis
Tumor Markers, Biological
| | Abstract | OBJECTIVE: To analyze the prognostic value of the preoperative serum levels of the carcinoembryonic antigen (CEA) in primary colorectal carcinoma.
MATERIAL AND METHODS: Preoperative serum levels of CEA were analyzed in 275 colorectal cancer patients, who were followed up for a minimum of 5 years, or until death.
RESULTS: The percentage of positivities for the preoperative serum levels of CEA (> 6 ng/ml) was positively and significantly associated with the tumoral stage (A: 10,5%; B: 38,8%; C: 32,2%; y D: 72%; p < 0,0001). In addition, the elevated serum values of the antigen were significantly associated, in the univariate analysis, with short survival in the overall group of patients (p < 0,0001). However, the multivariate analysis only showed an independent prognosis value of the CEA in the subgroup of patients with stage C tumors.
CONCLUSIONS: Preoperative serum levels of CEA may be useful to predict tumoral extension, and also for the prognosis regarding stage C colorectal cancer patients. | | Language | spa | | Pub Type(s) | Evaluation Studies
Journal Article
| | PubMed ID | 11470069 |
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