Parfenov AI, Vasil'ev IuV, Chikunova BZ, Parfenov DA, Sivash ES
[Comparative diagnostic value of data of intestinoscopy with biopsy obtained from different regions of the small intestine] [Journal Article]
Ter Arkh 2001; 73(8):38-43.
AIM: To study diagnostic value of intestinoscopy with biopsy of the mucosa from different portions of the small intestine in patients with chronic diarrhea and malabsorption.
MATERIAL AND METHODS: The examination of 116 patients with chronic diarrhea and malabsorption (endoscopic and histological study of biopsy specimens from different portions of the small intestine) detected gluten enteropathy (n = 51), Wipple's disease (n = 8), general variable hypogammaglobulinemia (n = 11), lymphangioectasy (n = 9), lymphangiomatosis (n = 1), lymphoma (n = 2), amyloidosis (n = 3), eosinophilic gastroenteritis (n = 1), duodenoejunitis without atrophy (n = 7). 23 patients had normal mucosa of the small intestine.
RESULTS: Pathological changes in the jejunum and duodenum were identical in glutenic enteropathy (GE), Wipple's disease (WD), variable hypogammaglobulinemia (VH) and amyloidosis.
CONCLUSION: For diagnosis of GE, WD, VH and amyloidosis it is sufficient to take biopsy from distal duodenum. Spot biopsy from sites of lymphostasis or nodular lymphoid hyperplasia is most informative for identification of lymphangioectasy, lymphangiomatosis and small intestinal lymphoma. Pathological changes in the ileum in GE, WD, VH and amyloidosis indicate severe total lesion of the small intestine.
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