| Title | Low molecular weight antioxidants and their role in skin ageing. | | Author(s) | Podda M, Grundmann-Kollmann M | | Institution | Department of Dermatology, J. W. Goethe University, Frankfurt, Germany. podda@em.uni-frankfurt.de | | Source | Clin Exp Dermatol 2001 Oct; 26(7):578-82. | | MeSH | Aged
Aged, 80 and over
Animals
Antioxidants
Dose-Response Relationship, Radiation
Humans
Middle Aged
Molecular Weight
Reactive Oxygen Species
Skin Aging
Ultraviolet Rays
| | Abstract | There is increasing evidence that reactive oxygen species play a pivotal role in the process of ageing. The skin, as the outermost barrier of the body, is exposed to various exogenous sources of oxidative stress, in particular UV-irradiation. These are believed to be responsible for the extrinsic type of skin ageing, termed photo-ageing. It therefore seems reasonable to try to increase levels of protective low molecular weight antioxidants through a diet rich in fruits and vegetables or by direct topical application. Indeed, various in vitro and animal studies have proved that low molecular weight antioxidants, especially vitamins C and E, ascorbate and tocopherol, as well as lipoic acid, exert protective effects against oxidative stress. However, controlled long-term studies on the efficacy of low molecular weight antioxidants in the prevention or treatment of skin ageing in humans are still lacking. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 11696061 |
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