Assessment of adenosine, arbutamine and dobutamine as pharmacological stress agents during (99m)Tc-tetrofosmin SPECT imaging: a randomized study. Nuclear medicine communications. [Nucl Med Commun] Journal article | | Title | Assessment of adenosine, arbutamine and dobutamine as pharmacological stress agents during (99m)Tc-tetrofosmin SPECT imaging: a randomized study. | | Author(s) | Wright DJ, Williams SG, Lindsay HS, Sheard KL, Thorley PJ, Sivananthan UM | | Institution | The Cardiothoracic Centre, Thomas Drive, Liverpool, L14 3PE, UK. jaywright34@hotmail.com | | Source | Nucl Med Commun 2001 Dec; 22(12):1305-11. | | MeSH | Adenosine
Adrenergic beta-Agonists
Blood Pressure
Catecholamines
Comparative Study
Coronary Disease
Cross-Over Studies
Dobutamine
Electrocardiography
Exercise Test
Female
Heart
Heart Rate
Hemodynamic Processes
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Observer Variation
Organophosphorus Compounds
Organotechnetium Compounds
Radiopharmaceuticals
Tomography, Emission-Computed, Single-Photon
| | Abstract | We evaluated the use of adenosine, dobutamine and arbutamine with (99m)Tc-tetrofosmin myocardial perfusion imaging. Forty patients under investigation for suspected coronary artery disease were recruited. Each had a resting scan and two separate stress scans on different days, in a randomized cross-over study. Resultant images were blindly reported in 13 segments per scan as normal, reversible or fixed defects. A score was given (0-3) for segmental defect severity. Haemodynamic responses were as expected for each agent. Subjective side effect scores did not differ overall between agents. Adenosine caused a significantly higher incidence of abnormal taste (54%) than dobutamine and arbutamine (both 23%) and a lower incidence of palpitations (25% vs 69% and 54%, respectively), all P<0.05. Arbutamine caused significantly more chest pain than adenosine (77% vs 46%) though less flushing (35% vs 68%), both P<0.05. Comparison of the results obtained showed highly significant levels of segmental agreement for visual and semi-quantitative analysis between adenosine and arbutamine, kappa value and correlation coefficient of 0.78 and 0.86, respectively, dobutamine and adenosine 0.69 and 0.78, and arbutamine and dobutamine 0.75 and 0.78, all P<0.0001. Adenosine, arbutamine and dobutamine differ in their haemodynamic response and side effect profile but provide highly comparable results during (99m)Tc SPECT imaging. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
| | PubMed ID | 11711900 |
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