| Title | Identification of viable myocardium early after acute myocardial infarction using closed-loop arbutamine echocardiography: comparison with positron emission tomography. | | Author(s) | Pierard LA, Melon PG, Lancellotti P, De Landsheere CM, Degueldre C, Kulbertus HE | | Institution | Department of Cardiology, University Hospital Sart Tilman Liège, Belgium. lpierard@chu.ulg.ac.be | | Source | Acta Cardiol 2001 Dec; 56(6):387-94. | | MeSH | Adrenergic beta-Agonists
Catecholamines
Comparative Study
Echocardiography
Female
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Myocardial Contraction
Myocardial Infarction
Radiopharmaceuticals
Research Support, Non-U.S. Gov't
Sensitivity and Specificity
Tomography, Emission-Computed
| | Abstract | OBJECTIVE: This study sought to evaluate the safety and efficacy of arbutamine echocardiography in identifying contractile reserve and predicting functional improvement early after acute myocardial infarction (AMI).
METHODS AND RESULTS: Seventeen patients with first AMI underwent arbutamine echocardiography 48 to 96 hours after AMI. Arbutamine was infused by a closed-loop delivery device.The heart rate slope was 4 beats/min and the heart rate target was 20 beats/min above baseline heart rate. A follow-up echocardiogram was obtained one month later. N-13 ammonia and F-18 FDG positron emission tomographic (PET) imaging were performed 6 +/- 2 days after AMI, before coronary angiography. Mean duration of arbutamine infusion was 6 +/- 2 min.There was no complication and there were no major side effects. Myocardial viability was identified with PET in 15 of the 17 patients. Contractile reserve was observed in 10 patients during arbutamine infusion. Functional recovery was identified in 12 patients. Sensitivity, specificity and accuracy of PET and arbutamine echocardiography for predicting functional recovery were 100%, 40%, 76% and 67%, 80%, 84%, respectively.
CONCLUSIONS: Low-dose arbutamine stress testing is safe early after AMI. Contractile reserve can be rapidly identified by echocardiography and is specific, but moderately sensitive for predicting reversible dysfunction. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 11791807 |
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