| Title | Antimicrobial activity of prosthetic heart valve sewing cuffs coated with minocycline and rifampin. | | Author(s) | Darouiche RO, Fowler VG, Adal K, Kielhofner M, Mansouri D, Reller LB | | Institution | Center for Prostheses Infection, Baylor College of Medicine and Veterans Affairs Medical Center, St. Luke's Episcopal Hospital, Houston, Texas 77030, USA. rdarouiche@aol.com | | Source | Antimicrob Agents Chemother 2002 Feb; 46(2):543-5. | | MeSH | Anti-Bacterial Agents
Antibiotics, Antitubercular
Bacillus
Drug Therapy, Combination
Heart Valve Prosthesis
Humans
Microbial Sensitivity Tests
Minocycline
Prosthesis-Related Infections
Rifampin
Staphylococcus epidermidis
| | Abstract | Prosthetic heart valve sewing cuffs coated with minocycline and rifampin exhibited in vitro zones of inhibition against all 52 tested clinical isolates responsible for prosthetic valve endocarditis. An in vitro elution study of these coated sewing cuffs demonstrated residual zones of inhibition against Staphylococcus epidermidis for at least 4 weeks. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
| | PubMed ID | 11796374 |
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