| Title | Cadmium exposure decreases androgen-dependent metabolism of acetohexamide in liver microsomes of male rats through its testicular toxicity. | | Author(s) | Shimada H, Yamaguchi S, Murata H, Otagiri M, Imamura Y | | Institution | Faculty of Education, Kumamoto University, 2-40-1, Kurokami, Kumamoto 860-8555, Japan. | | Source | Arch Toxicol 2002 Feb; 76(1):8-12. | | MeSH | Acetohexamide
Alcohol Oxidoreductases
Animals
Cadmium
Cytosol
Dose-Response Relationship, Drug
Drug Synergism
Hypoglycemic Agents
Injections, Intraperitoneal
Injections, Subcutaneous
Male
Microsomes, Liver
Orchiectomy
Rats
Rats, Wistar
Testis
Testosterone
| | Abstract | Administration of cadmium (Cd) at a dose of 1.23 mg/kg (2.0 mg/kg as CdCl(2)) markedly decreased the activity of an enzyme (acetohexamide reductase) catalysing the ketone-reduction of acetohexamide, an oral antidiabetic drug, in liver microsomes of male rats. However, the decreased enzyme activity was increased by repeated treatment with testosterone propionate (TP). When male rats were castrated and TP was given to the castrated ones, a similar decrease and increase, as described above, were observed in the microsomal enzyme activity. Cd exposure to male rats induced haemorrhage and atrophy of the testes and significantly diminished serum testosterone levels. There was no possibility that Cd accumulated in liver microsomes of male rats causing direct inhibition of the microsomal enzyme activity. We conclude that Cd exposure decreases androgen-dependent metabolism of acetohexamide in liver microsomes of male rats through its testicular toxicity. Cd exposure had no effect on acetohexamide reductase activity in liver cytosol of male rats. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 11875619 |
|
