Butalbital in the treatment of headache: history, pharmacology, and efficacy. Headache. [Headache] Journal article | | Title | Butalbital in the treatment of headache: history, pharmacology, and efficacy. | | Author(s) | Silberstein SD, McCrory DC | | Institution | Jefferson Headache Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA. | | Source | Headache 2001 Nov-Dec; 41(10):953-67. | | MeSH | Acute Disease
Analgesics
Barbiturates
Drug Combinations
Headache
Humans
Migraine Disorders
Tension-Type Headache
Treatment Outcome
| | Abstract | Analgesics containing butalbital compounded with aspirin, acetaminophen, and/or caffeine are widely used for the treatment of migraine and tension-type headache. The butalbital-containing compounds are efficacious in placebo-controlled trials among patients with episodic tension-type headaches. Despite their frequent clinical use for migraine, they have not been studied in placebo-controlled trials among patients with migraine. Barbiturates can produce intoxication, hangover, tolerance, dependence, and toxicity. Butalbital can result in intoxication that is clinically indistinguishable from that produced by alcohol. Butalbital-containing analgesics can produce drug-induced headache in addition to tolerance and dependence. Higher doses can produce withdrawal syndromes after discontinuation. Butalbital-containing analgesics may be effective as backup medications or when other medications are ineffective or cannot be used. Because of concerns about overuse, medication-overuse headache, and withdrawal, their use should be limited and carefully monitored. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 11903523 |
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