| Title | Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group. | | Author(s) | Morton CA, Brown SB, Collins S, Ibbotson S, Jenkinson H, Kurwa H, Langmack K, McKenna K, Moseley H, Pearse AD, Stringer M, Taylor DK, Wong G, Rhodes LE | | Institution | Department of Dermatology, Falkirk Royal Infirmary, Falkirk FK1 5QE, U.K. colin.morton@fvah.scot.nhs.uk | | Source | Br J Dermatol 2002 Apr; 146(4):552-67. | | MeSH | Aminolevulinic Acid
Bowen's Disease
Carcinoma, Basal Cell
Health Care Costs
Humans
Keratosis
Light
Photochemotherapy
Photosensitizing Agents
Precancerous Conditions
Radiometry
Research Support, Non-U.S. Gov't
Skin Diseases
Skin Neoplasms
| | Abstract | Topical photodynamic therapy (PDT) is effective in the treatment of certain non-melanoma skin cancers and is under evaluation in other dermatoses. Its development has been enhanced by a low rate of adverse events and good cosmesis. 5-Aminolaevulinic acid (ALA) is the main agent used, converted within cells into the photosensitizer protoporphyrin IX, with surface illumination then triggering the photodynamic reaction. Despite the relative simplicity of the technique, accurate dosimetry in PDT is complicated by multiple variables in drug formulation, delivery and duration of application, in addition to light-specific parameters. Several non-coherent and coherent light sources are effective in PDT. Optimal disease-specific irradiance, wavelength and total dose characteristics have yet to be established, and are compounded by difficulties comparing light sources. The carcinogenic risk of ALA-PDT appears to be low. Current evidence indicates topical PDT to be effective in actinic keratoses on the face and scalp, Bowen's disease and superficial basal cell carcinomas (BCCs). PDT may prove advantageous where size, site or number of lesions limits the efficacy and/or acceptability of conventional therapies. Topical ALA-PDT alone is a relatively poor option for both nodular BCCs and squamous cell carcinomas. Experience of the modality in other skin diseases remains limited; areas where there is potential benefit include viral warts, acne, psoriasis and cutaneous T-cell lymphoma. A recent British Photodermatology Group workshop considered published evidence on topical PDT in order to establish guidelines to promote the efficacy and safety of this increasingly practised treatment modality. | | Language | eng | | Pub Type(s) | Consensus Development Conference
Guideline
Journal Article
Practice Guideline
Review
| | PubMed ID | 11966684 |
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